Cargando…
Long-term efficacy and safety of the Dumon stent for benign tracheal stenosis: a meta-analysis
BACKGROUND: The short-term efficacy of Dumon stent has been well demonstrated. Across years, however, due to insufficient sample size and absent of the randomized controlled trial, no reliable conclusion could be reach for Dumon stent’s long-term efficacy. So, we conducted the first meta-analysis to...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867818/ https://www.ncbi.nlm.nih.gov/pubmed/33569188 http://dx.doi.org/10.21037/jtd-20-2327 |
_version_ | 1783648349866426368 |
---|---|
author | Chen, Di-Fei Chen, Yu Zhong, Chang-Hao Chen, Xiao-Bo Li, Shi-Yue |
author_facet | Chen, Di-Fei Chen, Yu Zhong, Chang-Hao Chen, Xiao-Bo Li, Shi-Yue |
author_sort | Chen, Di-Fei |
collection | PubMed |
description | BACKGROUND: The short-term efficacy of Dumon stent has been well demonstrated. Across years, however, due to insufficient sample size and absent of the randomized controlled trial, no reliable conclusion could be reach for Dumon stent’s long-term efficacy. So, we conducted the first meta-analysis to evaluate the long-term efficacy and safety of the Dumon stent for benign tracheal stenosis. METHODS: Data on related trials were obtained by doing a literature search in PubMed, Web of Science and Cochrane Library. Random-effect and fixed-effect models were used to calculate the efficacy and incidence of complication of Dumon stent placement. RESULTS: A total of 395 patients from 8 studies were included in this study, revealing that the stability rate was 41.12% (95% CI, 34.85–48.52%) of Dumon stenting. Further, a curative rate of 40.74% (95% CI, 34.92–47.53%), and efficacy of 75.49% (95% CI, 70.89–80.39%) were obtained from this study. Analysis of the incidence of complications indicated 25.04% of migration (95% CI, 17.52–35.79%), 15.66% granulation (95% CI, 9.39–26.11%) and 23.82% of mucus retention 23.82% (95% CI, 13.77–41.20%). CONCLUSIONS: Dumon stent has a moderate efficacy for treating benign tracheal stenosis with approximately 20% incidence of complication, regular bronchoscopy follow-up should be conducted. Thus, further research is required to modified Dumon stenting. |
format | Online Article Text |
id | pubmed-7867818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-78678182021-02-09 Long-term efficacy and safety of the Dumon stent for benign tracheal stenosis: a meta-analysis Chen, Di-Fei Chen, Yu Zhong, Chang-Hao Chen, Xiao-Bo Li, Shi-Yue J Thorac Dis Original Article BACKGROUND: The short-term efficacy of Dumon stent has been well demonstrated. Across years, however, due to insufficient sample size and absent of the randomized controlled trial, no reliable conclusion could be reach for Dumon stent’s long-term efficacy. So, we conducted the first meta-analysis to evaluate the long-term efficacy and safety of the Dumon stent for benign tracheal stenosis. METHODS: Data on related trials were obtained by doing a literature search in PubMed, Web of Science and Cochrane Library. Random-effect and fixed-effect models were used to calculate the efficacy and incidence of complication of Dumon stent placement. RESULTS: A total of 395 patients from 8 studies were included in this study, revealing that the stability rate was 41.12% (95% CI, 34.85–48.52%) of Dumon stenting. Further, a curative rate of 40.74% (95% CI, 34.92–47.53%), and efficacy of 75.49% (95% CI, 70.89–80.39%) were obtained from this study. Analysis of the incidence of complications indicated 25.04% of migration (95% CI, 17.52–35.79%), 15.66% granulation (95% CI, 9.39–26.11%) and 23.82% of mucus retention 23.82% (95% CI, 13.77–41.20%). CONCLUSIONS: Dumon stent has a moderate efficacy for treating benign tracheal stenosis with approximately 20% incidence of complication, regular bronchoscopy follow-up should be conducted. Thus, further research is required to modified Dumon stenting. AME Publishing Company 2021-01 /pmc/articles/PMC7867818/ /pubmed/33569188 http://dx.doi.org/10.21037/jtd-20-2327 Text en 2021 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Chen, Di-Fei Chen, Yu Zhong, Chang-Hao Chen, Xiao-Bo Li, Shi-Yue Long-term efficacy and safety of the Dumon stent for benign tracheal stenosis: a meta-analysis |
title | Long-term efficacy and safety of the Dumon stent for benign tracheal stenosis: a meta-analysis |
title_full | Long-term efficacy and safety of the Dumon stent for benign tracheal stenosis: a meta-analysis |
title_fullStr | Long-term efficacy and safety of the Dumon stent for benign tracheal stenosis: a meta-analysis |
title_full_unstemmed | Long-term efficacy and safety of the Dumon stent for benign tracheal stenosis: a meta-analysis |
title_short | Long-term efficacy and safety of the Dumon stent for benign tracheal stenosis: a meta-analysis |
title_sort | long-term efficacy and safety of the dumon stent for benign tracheal stenosis: a meta-analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867818/ https://www.ncbi.nlm.nih.gov/pubmed/33569188 http://dx.doi.org/10.21037/jtd-20-2327 |
work_keys_str_mv | AT chendifei longtermefficacyandsafetyofthedumonstentforbenigntrachealstenosisametaanalysis AT chenyu longtermefficacyandsafetyofthedumonstentforbenigntrachealstenosisametaanalysis AT zhongchanghao longtermefficacyandsafetyofthedumonstentforbenigntrachealstenosisametaanalysis AT chenxiaobo longtermefficacyandsafetyofthedumonstentforbenigntrachealstenosisametaanalysis AT lishiyue longtermefficacyandsafetyofthedumonstentforbenigntrachealstenosisametaanalysis |