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Histone crotonylation-centric gene regulation

Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histone crotonylation at DNA regulatory elements plays an important role in the activation of ge...

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Autores principales: Li, Kun, Wang, Ziqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868018/
https://www.ncbi.nlm.nih.gov/pubmed/33549150
http://dx.doi.org/10.1186/s13072-021-00385-9
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author Li, Kun
Wang, Ziqiang
author_facet Li, Kun
Wang, Ziqiang
author_sort Li, Kun
collection PubMed
description Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histone crotonylation at DNA regulatory elements plays an important role in the activation of gene transcription. However, among others, we have shown that elevated cellular crotonylation levels result in the inhibition of endocytosis-related gene expression and pro-growth gene expression, implicating the complexity of histone crotonylation in gene regulation. Therefore, it is important to understand how histone crotonylation is regulated and how it, in turn, regulates the expression of its target genes. In this review, we summarize the regulatory factors that control histone crotonylation and discuss the role of different histone crotonylation sites in regulating gene expression, while providing novel insights into the central role of histone crotonylation in gene regulation.
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spelling pubmed-78680182021-02-08 Histone crotonylation-centric gene regulation Li, Kun Wang, Ziqiang Epigenetics Chromatin Review Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histone crotonylation at DNA regulatory elements plays an important role in the activation of gene transcription. However, among others, we have shown that elevated cellular crotonylation levels result in the inhibition of endocytosis-related gene expression and pro-growth gene expression, implicating the complexity of histone crotonylation in gene regulation. Therefore, it is important to understand how histone crotonylation is regulated and how it, in turn, regulates the expression of its target genes. In this review, we summarize the regulatory factors that control histone crotonylation and discuss the role of different histone crotonylation sites in regulating gene expression, while providing novel insights into the central role of histone crotonylation in gene regulation. BioMed Central 2021-02-06 /pmc/articles/PMC7868018/ /pubmed/33549150 http://dx.doi.org/10.1186/s13072-021-00385-9 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Li, Kun
Wang, Ziqiang
Histone crotonylation-centric gene regulation
title Histone crotonylation-centric gene regulation
title_full Histone crotonylation-centric gene regulation
title_fullStr Histone crotonylation-centric gene regulation
title_full_unstemmed Histone crotonylation-centric gene regulation
title_short Histone crotonylation-centric gene regulation
title_sort histone crotonylation-centric gene regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868018/
https://www.ncbi.nlm.nih.gov/pubmed/33549150
http://dx.doi.org/10.1186/s13072-021-00385-9
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