Signaling pathways of EBV-induced oncogenesis

Epstein-Barr virus (EBV) is closely associated with multiple human cancers. EBV-associated cancers are mainly lymphomas derived from B cells and T cells (Hodgkin lymphoma, Burkitt lymphoma, NK/T-cell lymphoma, and posttransplant lymphoproliferative disorder (PTLD)) and carcinomas derived from epithe...

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Autores principales: Luo, Yin, Liu, Yitong, Wang, Chengkun, Gan, Runliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868022/
https://www.ncbi.nlm.nih.gov/pubmed/33549103
http://dx.doi.org/10.1186/s12935-021-01793-3
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author Luo, Yin
Liu, Yitong
Wang, Chengkun
Gan, Runliang
author_facet Luo, Yin
Liu, Yitong
Wang, Chengkun
Gan, Runliang
author_sort Luo, Yin
collection PubMed
description Epstein-Barr virus (EBV) is closely associated with multiple human cancers. EBV-associated cancers are mainly lymphomas derived from B cells and T cells (Hodgkin lymphoma, Burkitt lymphoma, NK/T-cell lymphoma, and posttransplant lymphoproliferative disorder (PTLD)) and carcinomas derived from epithelial cells (nasopharyngeal carcinoma and gastric carcinoma). EBV can induce oncogenesis in its host cell by activating various signaling pathways, such as nuclear factor-κB (NF-κB), phosphoinositide-3-kinase/protein kinase B (PI3K/AKT), Janus kinase/signal transducer and transcription activator (JAK/STAT), mitogen-activated protein kinase (MAPK), transforming growth factor-β (TGF-β), and Wnt/β-catenin, which are regulated by EBV-encoded proteins and noncoding RNA. In this review, we focus on the oncogenic roles of EBV that are mediated through the aforementioned signaling pathways.
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spelling pubmed-78680222021-02-08 Signaling pathways of EBV-induced oncogenesis Luo, Yin Liu, Yitong Wang, Chengkun Gan, Runliang Cancer Cell Int Review Epstein-Barr virus (EBV) is closely associated with multiple human cancers. EBV-associated cancers are mainly lymphomas derived from B cells and T cells (Hodgkin lymphoma, Burkitt lymphoma, NK/T-cell lymphoma, and posttransplant lymphoproliferative disorder (PTLD)) and carcinomas derived from epithelial cells (nasopharyngeal carcinoma and gastric carcinoma). EBV can induce oncogenesis in its host cell by activating various signaling pathways, such as nuclear factor-κB (NF-κB), phosphoinositide-3-kinase/protein kinase B (PI3K/AKT), Janus kinase/signal transducer and transcription activator (JAK/STAT), mitogen-activated protein kinase (MAPK), transforming growth factor-β (TGF-β), and Wnt/β-catenin, which are regulated by EBV-encoded proteins and noncoding RNA. In this review, we focus on the oncogenic roles of EBV that are mediated through the aforementioned signaling pathways. BioMed Central 2021-02-06 /pmc/articles/PMC7868022/ /pubmed/33549103 http://dx.doi.org/10.1186/s12935-021-01793-3 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Luo, Yin
Liu, Yitong
Wang, Chengkun
Gan, Runliang
Signaling pathways of EBV-induced oncogenesis
title Signaling pathways of EBV-induced oncogenesis
title_full Signaling pathways of EBV-induced oncogenesis
title_fullStr Signaling pathways of EBV-induced oncogenesis
title_full_unstemmed Signaling pathways of EBV-induced oncogenesis
title_short Signaling pathways of EBV-induced oncogenesis
title_sort signaling pathways of ebv-induced oncogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868022/
https://www.ncbi.nlm.nih.gov/pubmed/33549103
http://dx.doi.org/10.1186/s12935-021-01793-3
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