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Group A Streptococcus Antibiotic Resistance in Iranian Children: A Meta-analysis

OBJECTIVES: Streptococcus pyogenes is associated with mild to severe infections, particularly in children and young adults. Proper antimicrobial treatment of S. pyogenes infections is important to prevent post-streptococcal complications. Therefore, the purpose of this meta-analysis was to evaluate...

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Autores principales: Khademi, Farzad, Vaez, Hamid, Sahebkar, Amirhossein, Taheri, Ramezan Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OMJ 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868040/
https://www.ncbi.nlm.nih.gov/pubmed/33585043
http://dx.doi.org/10.5001/omj.2020.79
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author Khademi, Farzad
Vaez, Hamid
Sahebkar, Amirhossein
Taheri, Ramezan Ali
author_facet Khademi, Farzad
Vaez, Hamid
Sahebkar, Amirhossein
Taheri, Ramezan Ali
author_sort Khademi, Farzad
collection PubMed
description OBJECTIVES: Streptococcus pyogenes is associated with mild to severe infections, particularly in children and young adults. Proper antimicrobial treatment of S. pyogenes infections is important to prevent post-streptococcal complications. Therefore, the purpose of this meta-analysis was to evaluate the prevalence of S. pyogenes antibiotic resistance among Iranian children. METHODS: We identified all published studies up to 20 March 2019 related to S. pyogenes antibiotic resistance by searching Persian and English electronic databases. Search terms included S. pyogenes, children, and Iran. Out of 1022 publications, 12 articles were eligible and included based on the inclusion and exclusion criteria. RESULTS: Our analysis indicated the following prevalence pattern for S. pyogenes antimicrobial resistance in Iran: 4.2% to penicillin, 38.3% to amoxicillin, 5.4% to erythromycin, 12.0% to azithromycin, 12.6% to clarithromycin, 12.4% to clindamycin, 15.3% to rifampicin, 8.1% to ceftriaxone, 17.6% to cefixime, 36.9% to ampicillin, 14.1% to vancomycin, 8.4% to chloramphenicol, 30.4% to tetracycline, 8.8% to cefotaxime, 82.8% to trimethoprim/sulfamethoxazole, 39.6% to gentamicin, 11.9% to ofloxacin, 28.3% to carbenicillin, 3.1% to ciprofloxacin, 6.1% to imipenem, 18.2% to cephalothin, 57.6% to tobramycin, 49.3% to kanamycin, 79.0% to cloxacillin, 12.9% to cephalexin, 10.7% to cefazolin, and 89.5% to amoxicillin-clavulanic acid. CONCLUSIONS: Our findings suggest penicillin (in non-allergic children) and macrolides, lincosamides, and narrow-spectrum cephalosporins (in penicillin-allergic children) as the treatments of choice in Iran.
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spelling pubmed-78680402021-02-11 Group A Streptococcus Antibiotic Resistance in Iranian Children: A Meta-analysis Khademi, Farzad Vaez, Hamid Sahebkar, Amirhossein Taheri, Ramezan Ali Oman Med J Review Article OBJECTIVES: Streptococcus pyogenes is associated with mild to severe infections, particularly in children and young adults. Proper antimicrobial treatment of S. pyogenes infections is important to prevent post-streptococcal complications. Therefore, the purpose of this meta-analysis was to evaluate the prevalence of S. pyogenes antibiotic resistance among Iranian children. METHODS: We identified all published studies up to 20 March 2019 related to S. pyogenes antibiotic resistance by searching Persian and English electronic databases. Search terms included S. pyogenes, children, and Iran. Out of 1022 publications, 12 articles were eligible and included based on the inclusion and exclusion criteria. RESULTS: Our analysis indicated the following prevalence pattern for S. pyogenes antimicrobial resistance in Iran: 4.2% to penicillin, 38.3% to amoxicillin, 5.4% to erythromycin, 12.0% to azithromycin, 12.6% to clarithromycin, 12.4% to clindamycin, 15.3% to rifampicin, 8.1% to ceftriaxone, 17.6% to cefixime, 36.9% to ampicillin, 14.1% to vancomycin, 8.4% to chloramphenicol, 30.4% to tetracycline, 8.8% to cefotaxime, 82.8% to trimethoprim/sulfamethoxazole, 39.6% to gentamicin, 11.9% to ofloxacin, 28.3% to carbenicillin, 3.1% to ciprofloxacin, 6.1% to imipenem, 18.2% to cephalothin, 57.6% to tobramycin, 49.3% to kanamycin, 79.0% to cloxacillin, 12.9% to cephalexin, 10.7% to cefazolin, and 89.5% to amoxicillin-clavulanic acid. CONCLUSIONS: Our findings suggest penicillin (in non-allergic children) and macrolides, lincosamides, and narrow-spectrum cephalosporins (in penicillin-allergic children) as the treatments of choice in Iran. OMJ 2021-01-31 /pmc/articles/PMC7868040/ /pubmed/33585043 http://dx.doi.org/10.5001/omj.2020.79 Text en The OMJ is Published Bimonthly and Copyrighted 2021 by the OMSB. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC) 4.0 License. http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Review Article
Khademi, Farzad
Vaez, Hamid
Sahebkar, Amirhossein
Taheri, Ramezan Ali
Group A Streptococcus Antibiotic Resistance in Iranian Children: A Meta-analysis
title Group A Streptococcus Antibiotic Resistance in Iranian Children: A Meta-analysis
title_full Group A Streptococcus Antibiotic Resistance in Iranian Children: A Meta-analysis
title_fullStr Group A Streptococcus Antibiotic Resistance in Iranian Children: A Meta-analysis
title_full_unstemmed Group A Streptococcus Antibiotic Resistance in Iranian Children: A Meta-analysis
title_short Group A Streptococcus Antibiotic Resistance in Iranian Children: A Meta-analysis
title_sort group a streptococcus antibiotic resistance in iranian children: a meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868040/
https://www.ncbi.nlm.nih.gov/pubmed/33585043
http://dx.doi.org/10.5001/omj.2020.79
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