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Diagnosis and treatment of disseminated intravascular coagulation in COVID-19 patients: a scoping review
BACKGROUND: Disseminated intravascular coagulation (DIC) is noted in severe cases of coronavirus disease 2019 (COVID-19). Recently, a number of studies evaluating the diagnosis and treatment of DIC in COVID-19 patients have been reported. OBJECTIVE: The aim of this study is to identify existing gaps...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868079/ https://www.ncbi.nlm.nih.gov/pubmed/33550533 http://dx.doi.org/10.1007/s12185-021-03084-z |
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author | Mori, Hirotaka Ohkawara, Hiroshi Togawa, Ryuichi Rikimaru, Mami Shibata, Yoko Ikezoe, Takayuki |
author_facet | Mori, Hirotaka Ohkawara, Hiroshi Togawa, Ryuichi Rikimaru, Mami Shibata, Yoko Ikezoe, Takayuki |
author_sort | Mori, Hirotaka |
collection | PubMed |
description | BACKGROUND: Disseminated intravascular coagulation (DIC) is noted in severe cases of coronavirus disease 2019 (COVID-19). Recently, a number of studies evaluating the diagnosis and treatment of DIC in COVID-19 patients have been reported. OBJECTIVE: The aim of this study is to identify existing gaps where further research is needed on the diagnosis and treatment of DIC complicated by COVID-19. METHODS: We used the PRISMA Extension for Scoping Reviews. MEDLINE, CENTRAL, WHO-ICTRP, ClinicalTrial.gov and PROSPERO were searched from their inception to 6 October 2020. RESULTS: Seven studies were selected; five were already published and two are ongoing. DIC was diagnosed using the International Society on Thrombosis and Hemostasis (ISTH) DIC score (n = 4) and the sepsis-induced coagulopathy (SIC) DIC score (n = 5). Seven studies examined the effectiveness of low molecular weight heparin (LMWH); of these, four studies used a prophylactic dose and five used a therapeutic dose of LMWH. A prophylactic dose of unfractionated heparin (UFH) was investigated in two studies. CONCLUSION: Studies on DIC diagnostic criteria and anticoagulants were limited to the ISTH or SIC scores and heparinoids, particularly LMWH. Further studies are needed to compare these with other available DIC scoring systems and anticoagulants. |
format | Online Article Text |
id | pubmed-7868079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-78680792021-02-09 Diagnosis and treatment of disseminated intravascular coagulation in COVID-19 patients: a scoping review Mori, Hirotaka Ohkawara, Hiroshi Togawa, Ryuichi Rikimaru, Mami Shibata, Yoko Ikezoe, Takayuki Int J Hematol Review Article BACKGROUND: Disseminated intravascular coagulation (DIC) is noted in severe cases of coronavirus disease 2019 (COVID-19). Recently, a number of studies evaluating the diagnosis and treatment of DIC in COVID-19 patients have been reported. OBJECTIVE: The aim of this study is to identify existing gaps where further research is needed on the diagnosis and treatment of DIC complicated by COVID-19. METHODS: We used the PRISMA Extension for Scoping Reviews. MEDLINE, CENTRAL, WHO-ICTRP, ClinicalTrial.gov and PROSPERO were searched from their inception to 6 October 2020. RESULTS: Seven studies were selected; five were already published and two are ongoing. DIC was diagnosed using the International Society on Thrombosis and Hemostasis (ISTH) DIC score (n = 4) and the sepsis-induced coagulopathy (SIC) DIC score (n = 5). Seven studies examined the effectiveness of low molecular weight heparin (LMWH); of these, four studies used a prophylactic dose and five used a therapeutic dose of LMWH. A prophylactic dose of unfractionated heparin (UFH) was investigated in two studies. CONCLUSION: Studies on DIC diagnostic criteria and anticoagulants were limited to the ISTH or SIC scores and heparinoids, particularly LMWH. Further studies are needed to compare these with other available DIC scoring systems and anticoagulants. Springer Singapore 2021-02-07 2021 /pmc/articles/PMC7868079/ /pubmed/33550533 http://dx.doi.org/10.1007/s12185-021-03084-z Text en © Japanese Society of Hematology 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Mori, Hirotaka Ohkawara, Hiroshi Togawa, Ryuichi Rikimaru, Mami Shibata, Yoko Ikezoe, Takayuki Diagnosis and treatment of disseminated intravascular coagulation in COVID-19 patients: a scoping review |
title | Diagnosis and treatment of disseminated intravascular coagulation in COVID-19 patients: a scoping review |
title_full | Diagnosis and treatment of disseminated intravascular coagulation in COVID-19 patients: a scoping review |
title_fullStr | Diagnosis and treatment of disseminated intravascular coagulation in COVID-19 patients: a scoping review |
title_full_unstemmed | Diagnosis and treatment of disseminated intravascular coagulation in COVID-19 patients: a scoping review |
title_short | Diagnosis and treatment of disseminated intravascular coagulation in COVID-19 patients: a scoping review |
title_sort | diagnosis and treatment of disseminated intravascular coagulation in covid-19 patients: a scoping review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868079/ https://www.ncbi.nlm.nih.gov/pubmed/33550533 http://dx.doi.org/10.1007/s12185-021-03084-z |
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