Cargando…

A potent and selective small molecule inhibitor of myoferlin attenuates colorectal cancer progression

As a pivotal vesicular trafficking protein, Myoferlin (MYOF) has become an attractive target for cancer therapy. However, the roles of MYOF in colorectal cancer invasion remain enigmatic, and MYOF‐targeted therapy in this malignancy has not been explored. In the present study, we provided the first...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Yuan, Kan, Weiqiong, Li, Yunqi, Hao, Yun, Huang, Anling, Gu, Haijun, Wang, Minna, Wang, Qingqing, Chen, Jinlian, Sun, Zhenliang, Liu, Mingyao, Chen, Yihua, Yi, Zhengfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868085/ https://www.ncbi.nlm.nih.gov/pubmed/33634965 http://dx.doi.org/10.1002/ctm2.289

Ejemplares similares

A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer
por: Zhang, Tao, et al.
Publicado: (2018)

Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression
por: Lin, Qingxiang, et al.
Publicado: (2020)

A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis viaFAK pathway
por: Dai, Fujun, et al.
Publicado: (2015)

Myoferlin disturbs redox equilibrium to accelerate gastric cancer migration
por: Shi, Hailong, et al.
Publicado: (2022)

Myoferlin, a Membrane Protein with Emerging Oncogenic Roles
por: Dong, Yimin, et al.
Publicado: (2019)

Comprehensive Analysis of Myoferlin in Human Pancreatic Cancer via Bioinformatics
por: Pi, Rou, et al.
Publicado: (2021)

HBZ upregulates myoferlin expression to facilitate HTLV-1 infection
por: Polakowski, Nicholas, et al.
Publicado: (2023)

Discovery and Optimization of N-Substituted 2-(4-pyridinyl)thiazole carboxamides against Tumor Growth through Regulating Angiogenesis Signaling Pathways
por: Zhou, Wenbo, et al.
Publicado: (2016)

Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells
por: Rademaker, Gilles, et al.
Publicado: (2022)

Loss of Myoferlin Redirects Breast Cancer Cell Motility towards Collective Migration
por: Volakis, Leonithas I., et al.
Publicado: (2014)

Characterization Analysis of Schistosoma japonicum Plasma Membrane Repair Relative Gene Myoferlin
por: Xiong, Yanian, et al.
Publicado: (2013)

Prognostic role of myoferlin expression in patients with clear cell renal cell carcinoma
por: Song, Dae Hyun, et al.
Publicado: (2017)

Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes
por: Blomme, Arnaud, et al.
Publicado: (2016)

Correlation between myoferlin expression and lymph node metastasis in papillary thyroid carcinoma
por: Na, Ji Min, et al.
Publicado: (2022)

Myoferlin, a multifunctional protein in normal cells, has novel and key roles in various cancers
por: Zhu, Wei, et al.
Publicado: (2019)

Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis
por: Zhang, Yunhui, et al.
Publicado: (2022)

Myoferlin Expression and Its Correlation with FIGO Histologic Grading in Early-Stage Endometrioid Carcinoma
por: Kim, Min Hye, et al.
Publicado: (2018)

Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness
por: Rademaker, Gilles, et al.
Publicado: (2018)

Myoferlin Is a Yet Unknown Interactor of the Mitochondrial Dynamics’ Machinery in Pancreas Cancer Cells
por: Anania, Sandy, et al.
Publicado: (2020)

Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression
por: SONG, DAE HYUN, et al.
Publicado: (2016)

Myoferlin Regulates Wnt/β-Catenin Signaling-Mediated Skeletal Muscle Development by Stabilizing Dishevelled-2 Against Autophagy
por: Han, Shunshun, et al.
Publicado: (2019)

Ethyl‐N‐dodecanoyl‐l‐arginate hydrochloride combats pathogens with low‐resistance generation by membrane attack and modifies gut microbiota structure
por: Shao, Ting, et al.
Publicado: (2019)

A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells
por: Dai, Fujun, et al.
Publicado: (2012)

Myoferlin Depletion in Breast Cancer Cells Promotes Mesenchymal to Epithelial Shape Change and Stalls Invasion
por: Li, Ruth, et al.
Publicado: (2012)

Loss of dysferlin or myoferlin results in differential defects in excitation–contraction coupling in mouse skeletal muscle
por: Barefield, David Y., et al.
Publicado: (2021)

Coupling of Cell Surface Biotinylation and SILAC-Based Quantitative Proteomics Identified Myoferlin as a Potential Therapeutic Target for Nasopharyngeal Carcinoma Metastasis
por: Li, Maoyu, et al.
Publicado: (2021)

Expression of Myoferlin in Human Airway Epithelium and Its Role in Cell Adhesion and Zonula Occludens-1 Expression
por: Leung, Cleo, et al.
Publicado: (2012)

Myoferlin regulates epithelial cancer cell plasticity and migration through autocrine TGF-β1 signaling
por: Barnhouse, Victoria R., et al.
Publicado: (2018)

Myoferlin silencing inhibits VEGFR2-mediated proliferation of metastatic clear cell renal cell carcinoma
por: An, Hyo Jung, et al.
Publicado: (2019)

Preclinical characterization of WB737, a potent and selective STAT3 inhibitor, in natural killer/T‐cell lymphoma
por: Wang, Yali, et al.
Publicado: (2023)

Myoferlin Contributes to the Metastatic Phenotype of Pancreatic Cancer Cells by Enhancing Their Migratory Capacity through the Control of Oxidative Phosphorylation
por: Rademaker, Gilles, et al.
Publicado: (2019)

High expression of myoferlin is associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with HPV-status
por: Kumar, Bhavna, et al.
Publicado: (2016)

Down‐regulating Myoferlin inhibits the vasculogenic mimicry of melanoma via decreasing MMP‐2 and inducing mesenchymal‐to‐epithelial transition
por: Zhang, Wenxue, et al.
Publicado: (2017)

Targeting STAT3 by a small molecule suppresses pancreatic cancer progression
por: Chen, Huang, et al.
Publicado: (2021)

A muscle specific protein “myoferlin” modulates IL-6/STAT3 signaling by chaperoning activated STAT3 to nucleus
por: Yadav, Arti, et al.
Publicado: (2017)

Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis
por: Rademaker, Gilles, et al.
Publicado: (2019)

NLRP6, decreased in gastric cancer, suppresses tumorigenicity of gastric cancer cells
por: Wang, Qingqing, et al.
Publicado: (2018)

New, potent, small molecule agonists of tyrosine kinase receptors attenuate dry eye disease
por: Yu, Zhiyuan, et al.
Publicado: (2022)

Ailanthone: a new potential drug for castration-resistant prostate cancer
por: Peng, Shihong, et al.
Publicado: (2017)

c-Met and EPHA7 Receptor Tyrosine Kinases Are Related to Prognosis in Clear Cell Renal Cell Carcinoma: Focusing on the Association with Myoferlin Expression
por: Jung, Minsun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rjcmpnhig5kqij1bl4oh2eff3h