Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier

NaCT/SLC13A5 is a Na(+)-coupled transporter for citrate in hepatocytes, neurons, and testes. It is also called mINDY (mammalian ortholog of ‘I'm Not Dead Yet’ in Drosophila). Deletion of Slc13a5 in mice leads to an advantageous phenotype, protecting against diet-induced obesity, and diabetes. I...

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Detalles Bibliográficos
Autores principales: Kopel, Jonathan J., Bhutia, Yangzom D., Sivaprakasam, Sathish, Ganapathy, Vadivel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868109/
https://www.ncbi.nlm.nih.gov/pubmed/33544126
http://dx.doi.org/10.1042/BCJ20200877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868109/
https://www.ncbi.nlm.nih.gov/pubmed/33544126
http://dx.doi.org/10.1042/BCJ20200877

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