Targeting RNA-binding proteins in acute and chronic leukemia

RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant expression of alternatively spliced, modified, and stabilized mRNA transcripts is essential to self-renewal, proliferation, and...

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Detalles Bibliográficos
Autores principales: Elcheva, Irina A., Spiegelman, Vladimir S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868134/
https://www.ncbi.nlm.nih.gov/pubmed/33149266
http://dx.doi.org/10.1038/s41375-020-01066-4
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author Elcheva, Irina A.
Spiegelman, Vladimir S.
author_facet Elcheva, Irina A.
Spiegelman, Vladimir S.
author_sort Elcheva, Irina A.
collection PubMed
description RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant expression of alternatively spliced, modified, and stabilized mRNA transcripts is essential to self-renewal, proliferation, and adaptation to stress. In this review, we assess the impact of key families of RBPs in leukemogenesis, review progress in targeting those proteins with small molecules, and discuss how multilevel composition of posttranscriptional regulation of gene expression could be used for potential therapies in acute and chronic leukemia.
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spelling pubmed-78681342021-05-04 Targeting RNA-binding proteins in acute and chronic leukemia Elcheva, Irina A. Spiegelman, Vladimir S. Leukemia Article RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant expression of alternatively spliced, modified, and stabilized mRNA transcripts is essential to self-renewal, proliferation, and adaptation to stress. In this review, we assess the impact of key families of RBPs in leukemogenesis, review progress in targeting those proteins with small molecules, and discuss how multilevel composition of posttranscriptional regulation of gene expression could be used for potential therapies in acute and chronic leukemia. 2020-11-04 2021-02 /pmc/articles/PMC7868134/ /pubmed/33149266 http://dx.doi.org/10.1038/s41375-020-01066-4 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Elcheva, Irina A.
Spiegelman, Vladimir S.
Targeting RNA-binding proteins in acute and chronic leukemia
title Targeting RNA-binding proteins in acute and chronic leukemia
title_full Targeting RNA-binding proteins in acute and chronic leukemia
title_fullStr Targeting RNA-binding proteins in acute and chronic leukemia
title_full_unstemmed Targeting RNA-binding proteins in acute and chronic leukemia
title_short Targeting RNA-binding proteins in acute and chronic leukemia
title_sort targeting rna-binding proteins in acute and chronic leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868134/
https://www.ncbi.nlm.nih.gov/pubmed/33149266
http://dx.doi.org/10.1038/s41375-020-01066-4
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