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Rational Design of A Novel Small-Molecule HIV-1 Inactivator Targeting Both gp120 and gp41 of HIV-1

Virus inactivator can inactivate cell-free virions without relying on their replication cycle, potentially reducing the impact of viral infection on cells. Previously, we successfully constructed a HIV-1 protein inactivator, 2DLT, by conjugating the D1D2 region of CD4 to the fusion inhibitor T1144 v...

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Detalles Bibliográficos
Autores principales:	Pu, Jing, Dai, Yu, Wang, Qian, Lu, Lu, Zhang, Junqi, Xu, Wei, Xie, Lan, Wang, Shengqi, Yu, Fei, He, Xiaoyang, Jiang, Shibo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868322/ https://www.ncbi.nlm.nih.gov/pubmed/33569006 http://dx.doi.org/10.3389/fphar.2020.613361

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