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Defined Tau Phosphospecies Differentially Inhibit Fast Axonal Transport Through Activation of Two Independent Signaling Pathways
Tau protein is subject to phosphorylation by multiple kinases at more than 80 different sites. Some of these sites are associated with tau pathology and neurodegeneration, but other sites are modified in normal tau as well as in pathological tau. Although phosphorylation of tau at residues in the mi...
Autores principales: | Morris, Sarah L., Tsai, Ming-Ying, Aloe, Sarah, Bechberger, Karin, König, Svenja, Morfini, Gerardo, Brady, Scott T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868336/ https://www.ncbi.nlm.nih.gov/pubmed/33568975 http://dx.doi.org/10.3389/fnmol.2020.610037 |
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