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Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases

Senescent cells, which show the permanent growth arrest in response to various forms of stress, accumulate in the body with the progression of age, and are associated with aging and age-associated diseases. Although the senescent cells are growth arrested, they still demonstrate high metabolic rate...

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Autores principales: Ahmed, Rezwana, Nakahata, Yasukazu, Shinohara, Kazuyuki, Bessho, Yasumasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868379/
https://www.ncbi.nlm.nih.gov/pubmed/33568972
http://dx.doi.org/10.3389/fnins.2021.638122
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author Ahmed, Rezwana
Nakahata, Yasukazu
Shinohara, Kazuyuki
Bessho, Yasumasa
author_facet Ahmed, Rezwana
Nakahata, Yasukazu
Shinohara, Kazuyuki
Bessho, Yasumasa
author_sort Ahmed, Rezwana
collection PubMed
description Senescent cells, which show the permanent growth arrest in response to various forms of stress, accumulate in the body with the progression of age, and are associated with aging and age-associated diseases. Although the senescent cells are growth arrested, they still demonstrate high metabolic rate and altered gene expressions, indicating that senescent cells are still active. We recently showed that the circadian clock properties, namely phase and period of the cells, are altered with the establishment of replicative senescence. However, whether cellular senescence triggers the alteration of circadian clock properties in the cells is still unknown. In this study we show that the oxidative stress-induced premature senescence induces the alterations of the circadian clock, similar to the phenotypes of the replicative senescent cells. We found that the oxidative stress-induced premature senescent cells display the prolonged period and delayed phases. In addition, the magnitude of these changes intensified over time, indicating that cellular senescence changes the circadian clock properties. Our current results corroborate with our previous findings and further confirm that cellular senescence induces altered circadian clock properties, irrespective of the replicative senescence or the stress-induced premature senescence.
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spelling pubmed-78683792021-02-09 Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases Ahmed, Rezwana Nakahata, Yasukazu Shinohara, Kazuyuki Bessho, Yasumasa Front Neurosci Neuroscience Senescent cells, which show the permanent growth arrest in response to various forms of stress, accumulate in the body with the progression of age, and are associated with aging and age-associated diseases. Although the senescent cells are growth arrested, they still demonstrate high metabolic rate and altered gene expressions, indicating that senescent cells are still active. We recently showed that the circadian clock properties, namely phase and period of the cells, are altered with the establishment of replicative senescence. However, whether cellular senescence triggers the alteration of circadian clock properties in the cells is still unknown. In this study we show that the oxidative stress-induced premature senescence induces the alterations of the circadian clock, similar to the phenotypes of the replicative senescent cells. We found that the oxidative stress-induced premature senescent cells display the prolonged period and delayed phases. In addition, the magnitude of these changes intensified over time, indicating that cellular senescence changes the circadian clock properties. Our current results corroborate with our previous findings and further confirm that cellular senescence induces altered circadian clock properties, irrespective of the replicative senescence or the stress-induced premature senescence. Frontiers Media S.A. 2021-01-25 /pmc/articles/PMC7868379/ /pubmed/33568972 http://dx.doi.org/10.3389/fnins.2021.638122 Text en Copyright © 2021 Ahmed, Nakahata, Shinohara and Bessho. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ahmed, Rezwana
Nakahata, Yasukazu
Shinohara, Kazuyuki
Bessho, Yasumasa
Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases
title Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases
title_full Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases
title_fullStr Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases
title_full_unstemmed Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases
title_short Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases
title_sort cellular senescence triggers altered circadian clocks with a prolonged period and delayed phases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868379/
https://www.ncbi.nlm.nih.gov/pubmed/33568972
http://dx.doi.org/10.3389/fnins.2021.638122
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