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Paraneoplastic cerebellar degeneration as a presenting manifestation of non-Hodgkin’s lymphoma

BACKGROUND: Paraneoplastic Cerebellar degeneration (PCD) is one of the classical paraneoplastic syndromes (PNS) which is characterised by subacute onset, progressive cerebellar ataxia and is usually associated with small cell lung carcinoma, adeno carcinoma of breast and ovary followed by Hodgkin’s...

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Autores principales: Nanda, Satyan, Handa, Rahul, Prasad, Atul, Anand, Rajiv, Zutshi, Dhruv, Dass, Sujata K., Bedi, Prabhjeet Kaur, Pahuja, Aarti, Shah, Pankaj Kumar, Sharma, Bipan, Malhotra, Nalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868521/
https://www.ncbi.nlm.nih.gov/pubmed/33555484
http://dx.doi.org/10.1007/s10072-021-05046-z
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author Nanda, Satyan
Handa, Rahul
Prasad, Atul
Anand, Rajiv
Zutshi, Dhruv
Dass, Sujata K.
Bedi, Prabhjeet Kaur
Pahuja, Aarti
Shah, Pankaj Kumar
Sharma, Bipan
Malhotra, Nalin
author_facet Nanda, Satyan
Handa, Rahul
Prasad, Atul
Anand, Rajiv
Zutshi, Dhruv
Dass, Sujata K.
Bedi, Prabhjeet Kaur
Pahuja, Aarti
Shah, Pankaj Kumar
Sharma, Bipan
Malhotra, Nalin
author_sort Nanda, Satyan
collection PubMed
description BACKGROUND: Paraneoplastic Cerebellar degeneration (PCD) is one of the classical paraneoplastic syndromes (PNS) which is characterised by subacute onset, progressive cerebellar ataxia and is usually associated with small cell lung carcinoma, adeno carcinoma of breast and ovary followed by Hodgkin’s lymphoma. OBJECTIVE: We herein report a case of subacute onset, progressive cerebellar ataxia in a 37-year-old female, who on evaluation was found to have non-Hodgkin’s lymphoma and experienced good clinical response to treatment. DISCUSSION: As compared to solid tumours, chances of association of PNS with Lymphomas is quite low and there are only few case reports in the literature showing association of PCD with non-Hodgkin’s lymphoma. As PCD is one of the classical PNS, it is very important to identify subtle cerebellar manifestations in an otherwise apparently normal individual, as early diagnosis and aggressive treatment can immensely improve the mortality and morbidity associated with this syndrome. CONCLUSION: This case signifies the importance of suspecting PNS as an important differential diagnosis in a young patient presenting with subacute onset progressive cerebellar ataxia and evaluating her extensively for malignancy in spite of no paraneoplastic antibody been detected as early diagnosis and treatment can lead to gratifying response. We do agree that 2 weeks follow up is a short time interval to determine whether the response was sustained or not, for which a long term follow up is required.
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spelling pubmed-78685212021-02-09 Paraneoplastic cerebellar degeneration as a presenting manifestation of non-Hodgkin’s lymphoma Nanda, Satyan Handa, Rahul Prasad, Atul Anand, Rajiv Zutshi, Dhruv Dass, Sujata K. Bedi, Prabhjeet Kaur Pahuja, Aarti Shah, Pankaj Kumar Sharma, Bipan Malhotra, Nalin Neurol Sci Brief Communication BACKGROUND: Paraneoplastic Cerebellar degeneration (PCD) is one of the classical paraneoplastic syndromes (PNS) which is characterised by subacute onset, progressive cerebellar ataxia and is usually associated with small cell lung carcinoma, adeno carcinoma of breast and ovary followed by Hodgkin’s lymphoma. OBJECTIVE: We herein report a case of subacute onset, progressive cerebellar ataxia in a 37-year-old female, who on evaluation was found to have non-Hodgkin’s lymphoma and experienced good clinical response to treatment. DISCUSSION: As compared to solid tumours, chances of association of PNS with Lymphomas is quite low and there are only few case reports in the literature showing association of PCD with non-Hodgkin’s lymphoma. As PCD is one of the classical PNS, it is very important to identify subtle cerebellar manifestations in an otherwise apparently normal individual, as early diagnosis and aggressive treatment can immensely improve the mortality and morbidity associated with this syndrome. CONCLUSION: This case signifies the importance of suspecting PNS as an important differential diagnosis in a young patient presenting with subacute onset progressive cerebellar ataxia and evaluating her extensively for malignancy in spite of no paraneoplastic antibody been detected as early diagnosis and treatment can lead to gratifying response. We do agree that 2 weeks follow up is a short time interval to determine whether the response was sustained or not, for which a long term follow up is required. Springer International Publishing 2021-02-08 2021 /pmc/articles/PMC7868521/ /pubmed/33555484 http://dx.doi.org/10.1007/s10072-021-05046-z Text en © Fondazione Società Italiana di Neurologia 2021, corrected publication 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Communication
Nanda, Satyan
Handa, Rahul
Prasad, Atul
Anand, Rajiv
Zutshi, Dhruv
Dass, Sujata K.
Bedi, Prabhjeet Kaur
Pahuja, Aarti
Shah, Pankaj Kumar
Sharma, Bipan
Malhotra, Nalin
Paraneoplastic cerebellar degeneration as a presenting manifestation of non-Hodgkin’s lymphoma
title Paraneoplastic cerebellar degeneration as a presenting manifestation of non-Hodgkin’s lymphoma
title_full Paraneoplastic cerebellar degeneration as a presenting manifestation of non-Hodgkin’s lymphoma
title_fullStr Paraneoplastic cerebellar degeneration as a presenting manifestation of non-Hodgkin’s lymphoma
title_full_unstemmed Paraneoplastic cerebellar degeneration as a presenting manifestation of non-Hodgkin’s lymphoma
title_short Paraneoplastic cerebellar degeneration as a presenting manifestation of non-Hodgkin’s lymphoma
title_sort paraneoplastic cerebellar degeneration as a presenting manifestation of non-hodgkin’s lymphoma
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868521/
https://www.ncbi.nlm.nih.gov/pubmed/33555484
http://dx.doi.org/10.1007/s10072-021-05046-z
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