Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin

• All-trans retinoic acid (ATRA) and retinol significantly reduced ALDH1+ve cell subsets. • Co-treatment of ATRA or retinol with cisplatin significantly inhibited NSCLC cell survival. • Retinoic acid pathway inhibition induced apoptosis of chemo-resistant cells. • RAR and RXR nuclear receptors were...

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Autores principales: MacDonagh, Lauren, Santiago, Rhyla Mae, Gray, Steven G., Breen, Eamon, Cuffe, Sinead, Finn, Stephen P., O'Byrne, Kenneth J., Barr, Martin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868629/
https://www.ncbi.nlm.nih.gov/pubmed/33550205
http://dx.doi.org/10.1016/j.tranon.2021.101025
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author MacDonagh, Lauren
Santiago, Rhyla Mae
Gray, Steven G.
Breen, Eamon
Cuffe, Sinead
Finn, Stephen P.
O'Byrne, Kenneth J.
Barr, Martin P.
author_facet MacDonagh, Lauren
Santiago, Rhyla Mae
Gray, Steven G.
Breen, Eamon
Cuffe, Sinead
Finn, Stephen P.
O'Byrne, Kenneth J.
Barr, Martin P.
author_sort MacDonagh, Lauren
collection PubMed
description • All-trans retinoic acid (ATRA) and retinol significantly reduced ALDH1+ve cell subsets. • Co-treatment of ATRA or retinol with cisplatin significantly inhibited NSCLC cell survival. • Retinoic acid pathway inhibition induced apoptosis of chemo-resistant cells. • RAR and RXR nuclear receptors were altered in response to ATRA. • Targeting components of the vitamin A/retinoic acid axis can overcome cisplatin resistance in NSCLC.
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spelling pubmed-78686292021-02-19 Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin MacDonagh, Lauren Santiago, Rhyla Mae Gray, Steven G. Breen, Eamon Cuffe, Sinead Finn, Stephen P. O'Byrne, Kenneth J. Barr, Martin P. Transl Oncol Original Research • All-trans retinoic acid (ATRA) and retinol significantly reduced ALDH1+ve cell subsets. • Co-treatment of ATRA or retinol with cisplatin significantly inhibited NSCLC cell survival. • Retinoic acid pathway inhibition induced apoptosis of chemo-resistant cells. • RAR and RXR nuclear receptors were altered in response to ATRA. • Targeting components of the vitamin A/retinoic acid axis can overcome cisplatin resistance in NSCLC. Neoplasia Press 2021-02-05 /pmc/articles/PMC7868629/ /pubmed/33550205 http://dx.doi.org/10.1016/j.tranon.2021.101025 Text en © 2021 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research
MacDonagh, Lauren
Santiago, Rhyla Mae
Gray, Steven G.
Breen, Eamon
Cuffe, Sinead
Finn, Stephen P.
O'Byrne, Kenneth J.
Barr, Martin P.
Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin
title Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin
title_full Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin
title_fullStr Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin
title_full_unstemmed Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin
title_short Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin
title_sort exploitation of the vitamin a/retinoic acid axis depletes aldh1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868629/
https://www.ncbi.nlm.nih.gov/pubmed/33550205
http://dx.doi.org/10.1016/j.tranon.2021.101025
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