The role of RNA N(6)-methyladenosine methyltransferase in cancers

Modification of eukaryotic RNA by methylation of adenosine residues to generate N(6)-methyladenosine (m(6)A) is a highly prevalent process. m(6)A is dynamically regulated during cell metabolism and embryo development, and it is mainly involved in various aspects of RNA metabolism, including RNA splicing, processing, transport from the nucleus, translation, and degradation. Accumulating evidence shows that dynamic changes to m(6)A are closely related to the occurrence and development of cancer and that methyltransferases, as key elements in the dynamic regulation of m(6)A, play a crucial role in these processes. Therefore, in this review, we describe the role of methyltransferases as m(6)A writers in cancer and summarize their potential molecular mechanisms of action.