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The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients

BACKGROUND: Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. M...

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Autores principales: Canovi, Simone, Besutti, Giulia, Bonelli, Efrem, Iotti, Valentina, Ottone, Marta, Albertazzi, Laura, Zerbini, Alessandro, Pattacini, Pierpaolo, Giorgi Rossi, Paolo, Colla, Rossana, Fasano, Tommaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868898/
https://www.ncbi.nlm.nih.gov/pubmed/33557778
http://dx.doi.org/10.1186/s12879-021-05855-9
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author Canovi, Simone
Besutti, Giulia
Bonelli, Efrem
Iotti, Valentina
Ottone, Marta
Albertazzi, Laura
Zerbini, Alessandro
Pattacini, Pierpaolo
Giorgi Rossi, Paolo
Colla, Rossana
Fasano, Tommaso
author_facet Canovi, Simone
Besutti, Giulia
Bonelli, Efrem
Iotti, Valentina
Ottone, Marta
Albertazzi, Laura
Zerbini, Alessandro
Pattacini, Pierpaolo
Giorgi Rossi, Paolo
Colla, Rossana
Fasano, Tommaso
author_sort Canovi, Simone
collection PubMed
description BACKGROUND: Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. METHODS: This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2. RESULTS: Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation. CONCLUSIONS: Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-05855-9.
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spelling pubmed-78688982021-02-08 The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients Canovi, Simone Besutti, Giulia Bonelli, Efrem Iotti, Valentina Ottone, Marta Albertazzi, Laura Zerbini, Alessandro Pattacini, Pierpaolo Giorgi Rossi, Paolo Colla, Rossana Fasano, Tommaso BMC Infect Dis Research Article BACKGROUND: Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients. METHODS: This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2. RESULTS: Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation. CONCLUSIONS: Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-05855-9. BioMed Central 2021-02-08 /pmc/articles/PMC7868898/ /pubmed/33557778 http://dx.doi.org/10.1186/s12879-021-05855-9 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Canovi, Simone
Besutti, Giulia
Bonelli, Efrem
Iotti, Valentina
Ottone, Marta
Albertazzi, Laura
Zerbini, Alessandro
Pattacini, Pierpaolo
Giorgi Rossi, Paolo
Colla, Rossana
Fasano, Tommaso
The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients
title The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients
title_full The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients
title_fullStr The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients
title_full_unstemmed The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients
title_short The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients
title_sort association between clinical laboratory data and chest ct findings explains disease severity in a large italian cohort of covid-19 patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868898/
https://www.ncbi.nlm.nih.gov/pubmed/33557778
http://dx.doi.org/10.1186/s12879-021-05855-9
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