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Outcomes of cardiac surgery in senior aged patients with ventricular dysfunction: analysis of a large national database

OBJECTIVE: In patients undergoing cardiac surgery, reduced preoperative ejection fraction (EF) and senior age are associated with a worse outcome. As most outcome data available for these patients are mainly from Western surgical populations involving specific surgery types, our aim is to evaluate t...

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Autores principales: TANG, Han-Wei, CHEN, Kai, HOU, Jian-Feng, HUANG, Xiao-Hong, LIU, Sheng, MA, Han-Ping, HU, Sheng-Shou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868914/
https://www.ncbi.nlm.nih.gov/pubmed/33613654
http://dx.doi.org/10.11909/j.issn.1671-5411.2021.01.006
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author TANG, Han-Wei
CHEN, Kai
HOU, Jian-Feng
HUANG, Xiao-Hong
LIU, Sheng
MA, Han-Ping
HU, Sheng-Shou
author_facet TANG, Han-Wei
CHEN, Kai
HOU, Jian-Feng
HUANG, Xiao-Hong
LIU, Sheng
MA, Han-Ping
HU, Sheng-Shou
author_sort TANG, Han-Wei
collection PubMed
description OBJECTIVE: In patients undergoing cardiac surgery, reduced preoperative ejection fraction (EF) and senior age are associated with a worse outcome. As most outcome data available for these patients are mainly from Western surgical populations involving specific surgery types, our aim is to evaluate the real-world characteristics and perioperative outcomes of surgery in senior-aged heart failure patients with reduced EF across a broad range cardiac surgeries. METHODS: Data were obtained from the China Heart Failure Surgery Registry (China-HFSR) database, a nationwide multicenter registry study in mainland China. Multiple variable regression analysis was performed in patients over 75 years old to identify risk factors associated with mortality. RESULTS: From 2012 to 2017, 578 senior-aged (> 75 years) patients were enrolled in China HFSR, 21.1% of whom were female. Isolated coronary bypass grafting (CABG) were performed in 71.6% of patients, 10.1% of patients underwent isolated valve surgery and 8.7% received CABG combined with valve surgery. In-hospital mortality was 10.6%, and the major complication rate was 17.3%. Multivariate analysis identified diabetes mellitus (odds ratio (OR) = 1.985), increased creatinine (OR = 1.007), New York Heart Association (NYHA) Class III (OR = 1.408), NYHA class IV (OR = 1.955), cardiogenic shock (OR, 6.271), and preoperative intra-aortic balloon pump insertion (OR = 3.426) as independent predictors of in-hospital mortality. CONCLUSIONS: In senior-aged patients, preoperative evaluation should be carefully performed, and strict management of reversible factors needs more attention. Senior-aged patients commonly have a more severe disease status combined with more frequent comorbidities, which may lead to a high risk in mortality.
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spelling pubmed-78689142021-02-18 Outcomes of cardiac surgery in senior aged patients with ventricular dysfunction: analysis of a large national database TANG, Han-Wei CHEN, Kai HOU, Jian-Feng HUANG, Xiao-Hong LIU, Sheng MA, Han-Ping HU, Sheng-Shou J Geriatr Cardiol Research Article OBJECTIVE: In patients undergoing cardiac surgery, reduced preoperative ejection fraction (EF) and senior age are associated with a worse outcome. As most outcome data available for these patients are mainly from Western surgical populations involving specific surgery types, our aim is to evaluate the real-world characteristics and perioperative outcomes of surgery in senior-aged heart failure patients with reduced EF across a broad range cardiac surgeries. METHODS: Data were obtained from the China Heart Failure Surgery Registry (China-HFSR) database, a nationwide multicenter registry study in mainland China. Multiple variable regression analysis was performed in patients over 75 years old to identify risk factors associated with mortality. RESULTS: From 2012 to 2017, 578 senior-aged (> 75 years) patients were enrolled in China HFSR, 21.1% of whom were female. Isolated coronary bypass grafting (CABG) were performed in 71.6% of patients, 10.1% of patients underwent isolated valve surgery and 8.7% received CABG combined with valve surgery. In-hospital mortality was 10.6%, and the major complication rate was 17.3%. Multivariate analysis identified diabetes mellitus (odds ratio (OR) = 1.985), increased creatinine (OR = 1.007), New York Heart Association (NYHA) Class III (OR = 1.408), NYHA class IV (OR = 1.955), cardiogenic shock (OR, 6.271), and preoperative intra-aortic balloon pump insertion (OR = 3.426) as independent predictors of in-hospital mortality. CONCLUSIONS: In senior-aged patients, preoperative evaluation should be carefully performed, and strict management of reversible factors needs more attention. Senior-aged patients commonly have a more severe disease status combined with more frequent comorbidities, which may lead to a high risk in mortality. Science Press 2021-01-28 /pmc/articles/PMC7868914/ /pubmed/33613654 http://dx.doi.org/10.11909/j.issn.1671-5411.2021.01.006 Text en Copyright and License information: Journal of Geriatric Cardiology 2021 http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Research Article
TANG, Han-Wei
CHEN, Kai
HOU, Jian-Feng
HUANG, Xiao-Hong
LIU, Sheng
MA, Han-Ping
HU, Sheng-Shou
Outcomes of cardiac surgery in senior aged patients with ventricular dysfunction: analysis of a large national database
title Outcomes of cardiac surgery in senior aged patients with ventricular dysfunction: analysis of a large national database
title_full Outcomes of cardiac surgery in senior aged patients with ventricular dysfunction: analysis of a large national database
title_fullStr Outcomes of cardiac surgery in senior aged patients with ventricular dysfunction: analysis of a large national database
title_full_unstemmed Outcomes of cardiac surgery in senior aged patients with ventricular dysfunction: analysis of a large national database
title_short Outcomes of cardiac surgery in senior aged patients with ventricular dysfunction: analysis of a large national database
title_sort outcomes of cardiac surgery in senior aged patients with ventricular dysfunction: analysis of a large national database
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868914/
https://www.ncbi.nlm.nih.gov/pubmed/33613654
http://dx.doi.org/10.11909/j.issn.1671-5411.2021.01.006
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