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Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters

The expression of short hairpin RNAs (shRNAs) in cells has many potential therapeutic applications, including as a functional cure for HIV. The RNA polymerase III promoters H1, 7SK, and U6 have all been used to express shRNAs. However, there have been no direct and simultaneous comparisons of shRNA...

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Detalles Bibliográficos
Autores principales:	Goguen, Ryan P., Del Corpo, Olivier, Malard, Camille M.G., Daher, Aïcha, Alpuche-Lazcano, Sergio P., Chen, Michelle J., Scarborough, Robert J., Gatignol, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868930/ https://www.ncbi.nlm.nih.gov/pubmed/33614248 http://dx.doi.org/10.1016/j.omtn.2020.12.022

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