Engineered CAR-T cells targeting TAG-72 and CD47 in ovarian cancer

Chimeric antigen receptor (CAR) T cells have revolutionized blood cancer immunotherapy; however, their efficacy against solid tumors has been limited. A common mechanism of tumor escape from single target therapies is downregulation or mutational loss of the nominal epitope. Targeting multiple antig...

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Detalles Bibliográficos
Autores principales: Shu, Runzhe, Evtimov, Vera J., Hammett, Maree V., Nguyen, Nhu-Y N., Zhuang, Junli, Hudson, Peter J., Howard, Maureen C., Pupovac, Aleta, Trounson, Alan O., Boyd, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868933/
https://www.ncbi.nlm.nih.gov/pubmed/33614914
http://dx.doi.org/10.1016/j.omto.2021.01.002

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