A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells

Homeodomain-interacting protein kinase-2 (HIPK2) can either promote or inhibit transcription depending on cellular context. In this study, we show that a new HIPK2 isoform increases TEAD reporter activity in NSCLC cells. We detected HIPK2 copy number gain in 5/6 (83.3%) NSCLC cell lines. In NSCLC pa...

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Detalles Bibliográficos
Autores principales: Dai, Yuyuan, Kyoyama, Hiroyuki, Yang, Yi-Lin, Wang, Yucheng, Liu, Shu, Wang, Yinghao, Mao, Jian-Hua, Xu, Zhidong, Uematsu, Kazutsugu, Jablons, David M., You, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869571/
https://www.ncbi.nlm.nih.gov/pubmed/33613845
http://dx.doi.org/10.18632/oncotarget.27871

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