Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review

Leflunomide (LF) represents the prototype member of dihydroorotate dehydrogenase (DHODH) enzyme inhibitors. DHODH is a mitochondrial inner membrane enzyme responsible for catalytic conversion of dihydroorotate into orotate, a rate-limiting step in the de novo synthesis of the pyrimidine nucleotides....

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Detalles Bibliográficos
Autores principales: Alamri, Raghad D., Elmeligy, Mazen A., Albalawi, Ghadeer A., Alquayr, Sarah M., Alsubhi, Samaher S., El-Ghaiesh, Sabah H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869628/
https://www.ncbi.nlm.nih.gov/pubmed/33571819
http://dx.doi.org/10.1016/j.intimp.2021.107398

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