Inclusion of variants discovered from diverse populations improves polygenic risk score transferability

The majority of polygenic risk scores (PRSs) have been developed and optimized in individuals of European ancestry and may have limited generalizability across other ancestral populations. Understanding aspects of PRSs that contribute to this issue and determining solutions is complicated by disease...

Descripción completa

Detalles Bibliográficos
Autores principales: Cavazos, Taylor B., Witte, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869832/
https://www.ncbi.nlm.nih.gov/pubmed/33564748
http://dx.doi.org/10.1016/j.xhgg.2020.100017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869832/
https://www.ncbi.nlm.nih.gov/pubmed/33564748
http://dx.doi.org/10.1016/j.xhgg.2020.100017

Ejemplares similares