Cargando…
Inclusion of variants discovered from diverse populations improves polygenic risk score transferability
The majority of polygenic risk scores (PRSs) have been developed and optimized in individuals of European ancestry and may have limited generalizability across other ancestral populations. Understanding aspects of PRSs that contribute to this issue and determining solutions is complicated by disease...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869832/ https://www.ncbi.nlm.nih.gov/pubmed/33564748 http://dx.doi.org/10.1016/j.xhgg.2020.100017 |