Cargando…

IgH 3’ regulatory region increases ectopic class switch recombination

DNA lesions inflicted by activation-induced deaminase (AID) instrumentally initiate the processes reshaping immunoglobulin genes in mature B-cells, from local somatic hypermutation (SHM) to junctions of distant breaks during class switch recombination (CSR). It remains incompletely understood how th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Le Noir, Sandrine, Bonaud, Amélie, Hervé, Bastien, Baylet, Audrey, Boyer, François, Lecardeur, Sandrine, Oruc, Zeliha, Sirac, Christophe, Cogné, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7869978/ https://www.ncbi.nlm.nih.gov/pubmed/33556079 http://dx.doi.org/10.1371/journal.pgen.1009288

Ejemplares similares

Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3′ regulatory region
por: Rouaud, Pauline, et al.
Publicado: (2014)

The IgH locus 3′ cis-regulatory super-enhancer co-opts AID for allelic transvection
por: Le Noir, Sandrine, et al.
Publicado: (2017)

Functional anatomy of the immunoglobulin heavy chain 3΄ super-enhancer needs not only core enhancer elements but also their unique DNA context
por: Le Noir, Sandrine, et al.
Publicado: (2017)

UnAIDed Class Switching in Activated B-Cells Reveals Intrinsic Features of a Self-Cleaving IgH Locus
por: Dalloul, Iman, et al.
Publicado: (2021)

Locus suicide recombination actively occurs on the functionally rearranged IgH allele in B-cells from inflamed human lymphoid tissues
por: Dalloul, Iman, et al.
Publicado: (2019)

A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production
por: Srour, Nivine, et al.
Publicado: (2016)

Duplication of a germline promoter downstream of the IgH 3′ regulatory region impairs class switch recombination
por: Santos, Joana M., et al.
Publicado: (2018)

Long-range Oncogenic Activation of IgH/c-myc Translocations by the IgH 3’ Regulatory Region
por: Gostissa, Monica, et al.
Publicado: (2009)

Individual Substitution Mutations in the AID C Terminus That Ablate IgH Class Switch Recombination
por: Kadungure, Tatenda, et al.
Publicado: (2015)

CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination
por: Marina-Zárate, Ester, et al.
Publicado: (2017)

The IgH 3′ regulatory region influences lymphomagenesis in Igλ-Myc mice
por: Saad, Faten, et al.
Publicado: (2015)

Physiological role of the 3′IgH CBEs super-anchor in antibody class switching
por: Zhang, Xuefei, et al.
Publicado: (2021)

Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination
por: Thomas-Claudepierre, Anne-Sophie, et al.
Publicado: (2016)

RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination
por: Ribeiro de Almeida, Claudia, et al.
Publicado: (2018)

The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation
por: Martin, Ophélie A., et al.
Publicado: (2023)

The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination
por: Delgado-Benito, Verónica, et al.
Publicado: (2018)

Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination
por: Robert, Isabelle, et al.
Publicado: (2009)

Misregulation of the IgH Locus in Thymocytes
por: Kumari, Gita, et al.
Publicado: (2018)

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells
por: Rouaud, Pauline, et al.
Publicado: (2013)

E(μ) and 3′RR IgH enhancers show hierarchic unilateral dependence in mature B-cells
por: Saintamand, A., et al.
Publicado: (2017)

Attempts to evaluate locus suicide recombination and its potential role in B cell negative selection in the mouse
por: Denis-Lagache, Nicolas, et al.
Publicado: (2023)

The IgH 3′ regulatory region governs μ chain transcription in mature B lymphocytes and the B cell fate
por: Saintamand, Alexis, et al.
Publicado: (2015)

A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination
por: Rocha, Pedro P., et al.
Publicado: (2016)

Bromodomain and extraterminal (BET) protein inhibition of IgG/IgE production in murine B cells is counter‐balanced by a strong Th2 bias
por: Dalloul, Zeinab, et al.
Publicado: (2021)

A PTIP–PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex
por: Starnes, Linda M., et al.
Publicado: (2016)

Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching
por: Marchalot, Anne, et al.
Publicado: (2020)

Altered 3D chromatin structure permits inversional recombination at the IgH locus
por: Qiu, Xiang, et al.
Publicado: (2020)

Roles of G4-DNA and G4-RNA in Class Switch Recombination and Additional Regulations in B-Lymphocytes
por: Dézé, Ophélie, et al.
Publicado: (2023)

IgH Diversity In an Individual With Only One Million B Lymphocytes
por: Lee, Ada, et al.
Publicado: (1993)

Evolution of duplicated IgH loci in Atlantic salmon, Salmo salar
por: Yasuike, Motoshige, et al.
Publicado: (2010)

Nucleolar tethering mediates pairing between the IgH and Myc loci
por: Strongin, Daniel E, et al.
Publicado: (2014)

Three IgH isotypes, IgM, IgA and IgY are expressed in Gentoo penguin and zebra finch
por: Han, Binyue, et al.
Publicado: (2017)

Rad52 mediates class-switch DNA recombination to IgD
por: Xu, Yijiang, et al.
Publicado: (2022)

IgH gene rearrangements as plasma biomarkers in Non-Hodgkin's Lymphoma patients
por: He, Jian, et al.
Publicado: (2011)

Loop Extrusion Mediates Physiological IgH Locus Contraction For RAG Scanning
por: Dai, Hai-Qiang, et al.
Publicado: (2021)

Developmental Separation of V(D)J Recombinase Expression and Initiation of IgH Recombination in B Lineage Progenitors In Vivo
por: Borghesi, Lisa, et al.
Publicado: (2004)

A role for the IgH intronic enhancer Eμ in enforcing allelic exclusion
por: Li, Fubin, et al.
Publicado: (2009)

The IgH 3’ regulatory region and c-myc-induced B-cell lymphomagenesis
por: Ghazzaui, Nour, et al.
Publicado: (2016)

Different B cell subpopulations show distinct patterns in their IgH repertoire metrics
por: Ghraichy, Marie, et al.
Publicado: (2021)

Dutcher bodies in an IgA‐myeloma patient harbouring the FGFR3/IGH fusion
por: Manabe, Masahiro, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rcl3th7sl9918804egn33da3t3