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Optimal two-stage design of single arm Phase II clinical trials based on median event time test
The Phase II clinical trials aim to assess the therapeutic efficacy of a new drug. The therapeutic efficacy has been often quantified by response rate such as overall response rate or survival probability in the Phase II setting. However, there is a strong desire to use survival time, which is the g...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870013/ https://www.ncbi.nlm.nih.gov/pubmed/33556130 http://dx.doi.org/10.1371/journal.pone.0246448 |