Cargando…

Sleep architecture, obstructive sleep apnea and functional outcomes in adults with a history of Tick-borne encephalitis

Tick-borne encephalitis (TBE) is a widespread viral infection of the central nervous system with increasing incidence in Europe and northern Asia. Post-infectious sequelae are frequent, and patients with TBE commonly experience long-term fatigue and subjective sleep disturbances. Obstructive sleep a...

Descripción completa

Detalles Bibliográficos
Autores principales: Veje, Malin, Studahl, Marie, Thunström, Erik, Stentoft, Erika, Nolskog, Peter, Celik, Yeliz, Peker, Yüksel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870069/
https://www.ncbi.nlm.nih.gov/pubmed/33556106
http://dx.doi.org/10.1371/journal.pone.0246767
_version_ 1783648738327134208
author Veje, Malin
Studahl, Marie
Thunström, Erik
Stentoft, Erika
Nolskog, Peter
Celik, Yeliz
Peker, Yüksel
author_facet Veje, Malin
Studahl, Marie
Thunström, Erik
Stentoft, Erika
Nolskog, Peter
Celik, Yeliz
Peker, Yüksel
author_sort Veje, Malin
collection PubMed
description Tick-borne encephalitis (TBE) is a widespread viral infection of the central nervous system with increasing incidence in Europe and northern Asia. Post-infectious sequelae are frequent, and patients with TBE commonly experience long-term fatigue and subjective sleep disturbances. Obstructive sleep apnea (OSA) may be a contributing factor, and objective sleep studies with polysomnography (PSG) are lacking. Forty-two adults, 22 TBE patients (cases), diagnosed in Region Västra Götaland, Sweden, between 2012 and 2015, and 20 controls without a known TBE history, underwent an overnight PSG, respectively. All participants responded to questionnaires. The cases and controls were similar regarding age, sex, obesity, concomitant diseases, smoking, and alcohol habits. Despite similar PSG characteristics such as total sleep time and OSA severity indices, the TBE cases reported statistically more sleep-related functional impairment on the Functional Outcome of Sleep Questionnaire (FOSQ) compared with the controls (median scores 18.1 vs. 19.9; p<0.05). In a multivariate analysis, TBE correlated significantly with the lower FOSQ scores (unstandardized β −1.80 [%95 confidence interval −3.02 - −0.58]; p = 0.005) independent of age, sex, total sleep time and apnea-hypopnea-index. TBE cases with OSA reported the lowest scores on the FOSQ compared with the other subgroups with TBE or OSA alone, and the ones with neither TBE nor OSA. TBE is associated with impaired functional outcomes, in which concomitant OSA may worsen the subjective symptoms. Further studies are warranted to determine the effect of treatment of concomitant OSA on functional outcomes with regard to optimal rehabilitation of TBE.
format Online
Article
Text
id pubmed-7870069
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-78700692021-02-11 Sleep architecture, obstructive sleep apnea and functional outcomes in adults with a history of Tick-borne encephalitis Veje, Malin Studahl, Marie Thunström, Erik Stentoft, Erika Nolskog, Peter Celik, Yeliz Peker, Yüksel PLoS One Research Article Tick-borne encephalitis (TBE) is a widespread viral infection of the central nervous system with increasing incidence in Europe and northern Asia. Post-infectious sequelae are frequent, and patients with TBE commonly experience long-term fatigue and subjective sleep disturbances. Obstructive sleep apnea (OSA) may be a contributing factor, and objective sleep studies with polysomnography (PSG) are lacking. Forty-two adults, 22 TBE patients (cases), diagnosed in Region Västra Götaland, Sweden, between 2012 and 2015, and 20 controls without a known TBE history, underwent an overnight PSG, respectively. All participants responded to questionnaires. The cases and controls were similar regarding age, sex, obesity, concomitant diseases, smoking, and alcohol habits. Despite similar PSG characteristics such as total sleep time and OSA severity indices, the TBE cases reported statistically more sleep-related functional impairment on the Functional Outcome of Sleep Questionnaire (FOSQ) compared with the controls (median scores 18.1 vs. 19.9; p<0.05). In a multivariate analysis, TBE correlated significantly with the lower FOSQ scores (unstandardized β −1.80 [%95 confidence interval −3.02 - −0.58]; p = 0.005) independent of age, sex, total sleep time and apnea-hypopnea-index. TBE cases with OSA reported the lowest scores on the FOSQ compared with the other subgroups with TBE or OSA alone, and the ones with neither TBE nor OSA. TBE is associated with impaired functional outcomes, in which concomitant OSA may worsen the subjective symptoms. Further studies are warranted to determine the effect of treatment of concomitant OSA on functional outcomes with regard to optimal rehabilitation of TBE. Public Library of Science 2021-02-08 /pmc/articles/PMC7870069/ /pubmed/33556106 http://dx.doi.org/10.1371/journal.pone.0246767 Text en © 2021 Veje et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Veje, Malin
Studahl, Marie
Thunström, Erik
Stentoft, Erika
Nolskog, Peter
Celik, Yeliz
Peker, Yüksel
Sleep architecture, obstructive sleep apnea and functional outcomes in adults with a history of Tick-borne encephalitis
title Sleep architecture, obstructive sleep apnea and functional outcomes in adults with a history of Tick-borne encephalitis
title_full Sleep architecture, obstructive sleep apnea and functional outcomes in adults with a history of Tick-borne encephalitis
title_fullStr Sleep architecture, obstructive sleep apnea and functional outcomes in adults with a history of Tick-borne encephalitis
title_full_unstemmed Sleep architecture, obstructive sleep apnea and functional outcomes in adults with a history of Tick-borne encephalitis
title_short Sleep architecture, obstructive sleep apnea and functional outcomes in adults with a history of Tick-borne encephalitis
title_sort sleep architecture, obstructive sleep apnea and functional outcomes in adults with a history of tick-borne encephalitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870069/
https://www.ncbi.nlm.nih.gov/pubmed/33556106
http://dx.doi.org/10.1371/journal.pone.0246767
work_keys_str_mv AT vejemalin sleeparchitectureobstructivesleepapneaandfunctionaloutcomesinadultswithahistoryoftickborneencephalitis
AT studahlmarie sleeparchitectureobstructivesleepapneaandfunctionaloutcomesinadultswithahistoryoftickborneencephalitis
AT thunstromerik sleeparchitectureobstructivesleepapneaandfunctionaloutcomesinadultswithahistoryoftickborneencephalitis
AT stentofterika sleeparchitectureobstructivesleepapneaandfunctionaloutcomesinadultswithahistoryoftickborneencephalitis
AT nolskogpeter sleeparchitectureobstructivesleepapneaandfunctionaloutcomesinadultswithahistoryoftickborneencephalitis
AT celikyeliz sleeparchitectureobstructivesleepapneaandfunctionaloutcomesinadultswithahistoryoftickborneencephalitis
AT pekeryuksel sleeparchitectureobstructivesleepapneaandfunctionaloutcomesinadultswithahistoryoftickborneencephalitis