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A review of methods for addressing components of interventions in meta-analysis

Many healthcare interventions are complex, consisting of multiple, possibly interacting, components. Several methodological articles addressing complex interventions in the meta-analytical context have been published. We hereby provide an overview of methods used to evaluate the effects of complex i...

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Detalles Bibliográficos
Autores principales: Petropoulou, Maria, Efthimiou, Orestis, Rücker, Gerta, Schwarzer, Guido, Furukawa, Toshi A., Pompoli, Alessandro, Koek, Huiberdina L., Del Giovane, Cinzia, Rodondi, Nicolas, Mavridis, Dimitris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870082/
https://www.ncbi.nlm.nih.gov/pubmed/33556155
http://dx.doi.org/10.1371/journal.pone.0246631
Descripción
Sumario:Many healthcare interventions are complex, consisting of multiple, possibly interacting, components. Several methodological articles addressing complex interventions in the meta-analytical context have been published. We hereby provide an overview of methods used to evaluate the effects of complex interventions with meta-analytical models. We summarized the methodology, highlighted new developments, and described the benefits, drawbacks, and potential challenges of each identified method. We expect meta-analytical methods focusing on components of several multicomponent interventions to become increasingly popular due to recently developed, easy-to-use, software tools that can be used to conduct the relevant analyses. The different meta-analytical methods are illustrated through two examples comparing psychotherapies for panic disorder.