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Implementation of pre-exposure prophylaxis programme in Spain. Feasibility of four different delivery models
BACKGROUND: Pre-exposure prophylaxis (PrEP) is an effective and cost-effective strategy for HIV prevention. Spain carried out an implementation study in order to assess the feasibility of implementing PrEP programmes within its heterogeneous health system. METHODS: Observational longitudinal study c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870089/ https://www.ncbi.nlm.nih.gov/pubmed/33556085 http://dx.doi.org/10.1371/journal.pone.0246129 |
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author | Iniesta, Carlos Coll, Pep Barberá, María Jesús García Deltoro, Miguel Camino, Xabier Fagúndez, Gabriela Díaz, Asunción Polo, Rosa |
author_facet | Iniesta, Carlos Coll, Pep Barberá, María Jesús García Deltoro, Miguel Camino, Xabier Fagúndez, Gabriela Díaz, Asunción Polo, Rosa |
author_sort | Iniesta, Carlos |
collection | PubMed |
description | BACKGROUND: Pre-exposure prophylaxis (PrEP) is an effective and cost-effective strategy for HIV prevention. Spain carried out an implementation study in order to assess the feasibility of implementing PrEP programmes within its heterogeneous health system. METHODS: Observational longitudinal study conducted on four different types of health-care setting: a community centre (CC), a sexually transmitted infections clinic (STIC), a hospital-based HIV unit (HBHIVU) and a hospital-based STI unit (HBSTIU). We recruited gay, bisexual and other men who have sex with men (GBSM) and transgender women at risk of HIV infections, gave them PrEP and monitored clinical, behavioural PrEP-related and satisfaction information for 52 weeks. We collected perceptions on PrEP implementation feasibility from health-care professionals participating in the study. RESULTS: A total of 321 participants were recruited, with 99.1% being GBMSM. Overall retention was 87.2% and it was highest at the CC (92.6%). Condom use decreased during the study period, while STIs did not increase consistently. The percentage of people who did not miss any doses of PrEP during the previous week remained at over 93%. No HIV seroconversions occurred. We observed overall decreases in GHB (32.5% to 21.8%), cocaine (27.5% to 21.4%), MDMA (25.7% to 14.3%), speed (11.4% to 5.7%) and mephedrone use (10.7% to 5.0%). The overall participant satisfaction with PrEP was 98.6%. Health-care professionals’ perceptions of PrEP feasibility were positive, except for the lack of personnel. CONCLUSIONS: PrEP implementation is feasible in four types of health-care settings. Local specificities have to be taken into consideration while implementing PrEP. |
format | Online Article Text |
id | pubmed-7870089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-78700892021-02-11 Implementation of pre-exposure prophylaxis programme in Spain. Feasibility of four different delivery models Iniesta, Carlos Coll, Pep Barberá, María Jesús García Deltoro, Miguel Camino, Xabier Fagúndez, Gabriela Díaz, Asunción Polo, Rosa PLoS One Research Article BACKGROUND: Pre-exposure prophylaxis (PrEP) is an effective and cost-effective strategy for HIV prevention. Spain carried out an implementation study in order to assess the feasibility of implementing PrEP programmes within its heterogeneous health system. METHODS: Observational longitudinal study conducted on four different types of health-care setting: a community centre (CC), a sexually transmitted infections clinic (STIC), a hospital-based HIV unit (HBHIVU) and a hospital-based STI unit (HBSTIU). We recruited gay, bisexual and other men who have sex with men (GBSM) and transgender women at risk of HIV infections, gave them PrEP and monitored clinical, behavioural PrEP-related and satisfaction information for 52 weeks. We collected perceptions on PrEP implementation feasibility from health-care professionals participating in the study. RESULTS: A total of 321 participants were recruited, with 99.1% being GBMSM. Overall retention was 87.2% and it was highest at the CC (92.6%). Condom use decreased during the study period, while STIs did not increase consistently. The percentage of people who did not miss any doses of PrEP during the previous week remained at over 93%. No HIV seroconversions occurred. We observed overall decreases in GHB (32.5% to 21.8%), cocaine (27.5% to 21.4%), MDMA (25.7% to 14.3%), speed (11.4% to 5.7%) and mephedrone use (10.7% to 5.0%). The overall participant satisfaction with PrEP was 98.6%. Health-care professionals’ perceptions of PrEP feasibility were positive, except for the lack of personnel. CONCLUSIONS: PrEP implementation is feasible in four types of health-care settings. Local specificities have to be taken into consideration while implementing PrEP. Public Library of Science 2021-02-08 /pmc/articles/PMC7870089/ /pubmed/33556085 http://dx.doi.org/10.1371/journal.pone.0246129 Text en © 2021 Iniesta et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Iniesta, Carlos Coll, Pep Barberá, María Jesús García Deltoro, Miguel Camino, Xabier Fagúndez, Gabriela Díaz, Asunción Polo, Rosa Implementation of pre-exposure prophylaxis programme in Spain. Feasibility of four different delivery models |
title | Implementation of pre-exposure prophylaxis programme in Spain. Feasibility of four different delivery models |
title_full | Implementation of pre-exposure prophylaxis programme in Spain. Feasibility of four different delivery models |
title_fullStr | Implementation of pre-exposure prophylaxis programme in Spain. Feasibility of four different delivery models |
title_full_unstemmed | Implementation of pre-exposure prophylaxis programme in Spain. Feasibility of four different delivery models |
title_short | Implementation of pre-exposure prophylaxis programme in Spain. Feasibility of four different delivery models |
title_sort | implementation of pre-exposure prophylaxis programme in spain. feasibility of four different delivery models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870089/ https://www.ncbi.nlm.nih.gov/pubmed/33556085 http://dx.doi.org/10.1371/journal.pone.0246129 |
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