SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review

The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based expla...

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Autores principales: Menezes, Maria Clara Saad, Pestana, Diego Vinicius Santinelli, Gameiro, Gustavo Rosa, da Silva, Luiz Fernando Ferraz, Baron, Ėlodie, Rouby, Jean-Jacques, Auler Jr, José Otavio Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870126/
https://www.ncbi.nlm.nih.gov/pubmed/33557908
http://dx.doi.org/10.1186/s13054-020-03399-z
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author Menezes, Maria Clara Saad
Pestana, Diego Vinicius Santinelli
Gameiro, Gustavo Rosa
da Silva, Luiz Fernando Ferraz
Baron, Ėlodie
Rouby, Jean-Jacques
Auler Jr, José Otavio Costa
author_facet Menezes, Maria Clara Saad
Pestana, Diego Vinicius Santinelli
Gameiro, Gustavo Rosa
da Silva, Luiz Fernando Ferraz
Baron, Ėlodie
Rouby, Jean-Jacques
Auler Jr, José Otavio Costa
author_sort Menezes, Maria Clara Saad
collection PubMed
description The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based explanations for the immune response, and COVID-19-associated hypercoagulability.
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spelling pubmed-78701262021-02-09 SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review Menezes, Maria Clara Saad Pestana, Diego Vinicius Santinelli Gameiro, Gustavo Rosa da Silva, Luiz Fernando Ferraz Baron, Ėlodie Rouby, Jean-Jacques Auler Jr, José Otavio Costa Crit Care Review The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based explanations for the immune response, and COVID-19-associated hypercoagulability. BioMed Central 2021-02-08 /pmc/articles/PMC7870126/ /pubmed/33557908 http://dx.doi.org/10.1186/s13054-020-03399-z Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Menezes, Maria Clara Saad
Pestana, Diego Vinicius Santinelli
Gameiro, Gustavo Rosa
da Silva, Luiz Fernando Ferraz
Baron, Ėlodie
Rouby, Jean-Jacques
Auler Jr, José Otavio Costa
SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review
title SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review
title_full SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review
title_fullStr SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review
title_full_unstemmed SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review
title_short SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review
title_sort sars-cov-2 pneumonia—receptor binding and lung immunopathology: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870126/
https://www.ncbi.nlm.nih.gov/pubmed/33557908
http://dx.doi.org/10.1186/s13054-020-03399-z
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