TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin

TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor formation. TRIM37 depletion from tissue culture cells results in supernumerary foci bearing the centriolar protein Centrin. Here, we characterize these centriolar protein assemblies...

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Detalles Bibliográficos
Autores principales: Balestra, Fernando R, Domínguez-Calvo, Andrés, Wolf, Benita, Busso, Coralie, Buff, Alizée, Averink, Tessa, Lipsanen-Nyman, Marita, Huertas, Pablo, Ríos, Rosa M, Gönczy, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870141/
https://www.ncbi.nlm.nih.gov/pubmed/33491649
http://dx.doi.org/10.7554/eLife.62640

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