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The relationship of irisin with metabolic syndrome components and insulin secretion and resistance in schoolchildren
Irisin, a novel myokine, is believed to be the crucial factor in converting white adipose tissue to beige adipose tissue. For this paper, we studied the relationship among irisin and components of metabolic syndrome (MetS), and insulin secretion and resistance in schoolchildren of Taiwan. Subjects r...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870195/ https://www.ncbi.nlm.nih.gov/pubmed/33592858 http://dx.doi.org/10.1097/MD.0000000000024061 |
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author | Wu, Chung-Ze Chu, Nain-Feng Chang, Li-Chien Cheng, Chao-Wen Lin, Yuh-Feng Pei, Dee Fang, Te-Chao Chen, Jin-Shuen |
author_facet | Wu, Chung-Ze Chu, Nain-Feng Chang, Li-Chien Cheng, Chao-Wen Lin, Yuh-Feng Pei, Dee Fang, Te-Chao Chen, Jin-Shuen |
author_sort | Wu, Chung-Ze |
collection | PubMed |
description | Irisin, a novel myokine, is believed to be the crucial factor in converting white adipose tissue to beige adipose tissue. For this paper, we studied the relationship among irisin and components of metabolic syndrome (MetS), and insulin secretion and resistance in schoolchildren of Taiwan. Subjects receiving routine annual health examination at elementary school were enrolled. Demographic data, anthropometry, MetS components, irisin, and insulin secretion and resistance were collected. Subjects were divided into normal, overweight, and obese groups for evaluation of irisin in obesity. Finally, the relationship between irisin and MetS was analyzed. There were 376 children (179 boys and 197 girls), aged 10.3 ± 1.5 years, were enrolled. In boys, irisin levels were not associated with body mass index percentile, body fat, blood pressure, lipid profiles, insulin secretion or resistance. After adjusting for age, the irisin level in boys was negatively related to fasting plasma glucose (FPG) (r = –0.21, P = .006). In girls, after adjusting for age, the irisin levels were positively related only to FPG (r = 1.49, P = .038). In both genders, irisin levels were similar among normal, overweight, and obese groups, and between subjects with and without MetS. The irisin levels were not associated with MetS in either boys or girls. In girls, circulating irisin levels have a nonsignificant declining trend in overweight and obese girls. However, irisin levels were negatively related to FPG in boys and positively related to FPG in girls. The contrary relationship between irisin and FPG in boys and girls needs further exploration. |
format | Online Article Text |
id | pubmed-7870195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-78701952021-02-10 The relationship of irisin with metabolic syndrome components and insulin secretion and resistance in schoolchildren Wu, Chung-Ze Chu, Nain-Feng Chang, Li-Chien Cheng, Chao-Wen Lin, Yuh-Feng Pei, Dee Fang, Te-Chao Chen, Jin-Shuen Medicine (Baltimore) 5500 Irisin, a novel myokine, is believed to be the crucial factor in converting white adipose tissue to beige adipose tissue. For this paper, we studied the relationship among irisin and components of metabolic syndrome (MetS), and insulin secretion and resistance in schoolchildren of Taiwan. Subjects receiving routine annual health examination at elementary school were enrolled. Demographic data, anthropometry, MetS components, irisin, and insulin secretion and resistance were collected. Subjects were divided into normal, overweight, and obese groups for evaluation of irisin in obesity. Finally, the relationship between irisin and MetS was analyzed. There were 376 children (179 boys and 197 girls), aged 10.3 ± 1.5 years, were enrolled. In boys, irisin levels were not associated with body mass index percentile, body fat, blood pressure, lipid profiles, insulin secretion or resistance. After adjusting for age, the irisin level in boys was negatively related to fasting plasma glucose (FPG) (r = –0.21, P = .006). In girls, after adjusting for age, the irisin levels were positively related only to FPG (r = 1.49, P = .038). In both genders, irisin levels were similar among normal, overweight, and obese groups, and between subjects with and without MetS. The irisin levels were not associated with MetS in either boys or girls. In girls, circulating irisin levels have a nonsignificant declining trend in overweight and obese girls. However, irisin levels were negatively related to FPG in boys and positively related to FPG in girls. The contrary relationship between irisin and FPG in boys and girls needs further exploration. Lippincott Williams & Wilkins 2021-02-05 /pmc/articles/PMC7870195/ /pubmed/33592858 http://dx.doi.org/10.1097/MD.0000000000024061 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5500 Wu, Chung-Ze Chu, Nain-Feng Chang, Li-Chien Cheng, Chao-Wen Lin, Yuh-Feng Pei, Dee Fang, Te-Chao Chen, Jin-Shuen The relationship of irisin with metabolic syndrome components and insulin secretion and resistance in schoolchildren |
title | The relationship of irisin with metabolic syndrome components and insulin secretion and resistance in schoolchildren |
title_full | The relationship of irisin with metabolic syndrome components and insulin secretion and resistance in schoolchildren |
title_fullStr | The relationship of irisin with metabolic syndrome components and insulin secretion and resistance in schoolchildren |
title_full_unstemmed | The relationship of irisin with metabolic syndrome components and insulin secretion and resistance in schoolchildren |
title_short | The relationship of irisin with metabolic syndrome components and insulin secretion and resistance in schoolchildren |
title_sort | relationship of irisin with metabolic syndrome components and insulin secretion and resistance in schoolchildren |
topic | 5500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870195/ https://www.ncbi.nlm.nih.gov/pubmed/33592858 http://dx.doi.org/10.1097/MD.0000000000024061 |
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