Systemic inflammatory status – a bridge between gestational weight gain and neonatal outcomes (STROBE-compliant article)

Pregnant women with excessive gestational weight gain express an inflammatory status with multiple negative effects on birth outcomes. The aim of this study was to identify the relationship between gestational weight gain at different gestational ages and inflammatory status in pregnant women and th...

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Autores principales: Rugină, Cosmin, Mărginean, Cristina Oana, Meliţ, Lorena Elena, Huţanu, Adina, Ghiga, Dana Valentina, Modi, Viviana, Mărginean, Claudiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870210/
https://www.ncbi.nlm.nih.gov/pubmed/33592904
http://dx.doi.org/10.1097/MD.0000000000024511
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author Rugină, Cosmin
Mărginean, Cristina Oana
Meliţ, Lorena Elena
Huţanu, Adina
Ghiga, Dana Valentina
Modi, Viviana
Mărginean, Claudiu
author_facet Rugină, Cosmin
Mărginean, Cristina Oana
Meliţ, Lorena Elena
Huţanu, Adina
Ghiga, Dana Valentina
Modi, Viviana
Mărginean, Claudiu
author_sort Rugină, Cosmin
collection PubMed
description Pregnant women with excessive gestational weight gain express an inflammatory status with multiple negative effects on birth outcomes. The aim of this study was to identify the relationship between gestational weight gain at different gestational ages and inflammatory status in pregnant women and their newborns assessing both interleukin 6 and 8, as well as hepcidin in these couples. Our study included 170 pregnant women and their newborns. Pregnant women were clinically assessed at the end of the 1(st) trimester and at term, whereas the newborns were assessed over the first 3 days of life. The levels of interleukin 6, 8 and hepcidin were measured in both pregnant women and their newborns. We noticed higher levels of interleukin 6, interleukin 8 and hepcidin in pregnant women at the time of delivery as compared to the end of the 1st trimester. We observed a direct significant correlation between gestational weight gain at the time of delivery and interleukin 8 in both mothers [r = 0.1834, 95% CI: 0.0293–0.3290, (P = .0167)] and newborns [r = 0.1790, 95% CI: 0.0248–0.3249, (P = .0195)]. Our study underlined that a higher gestational weight gain resulted in a significantly higher birth weight [r = 0.2190, 95% CI: 0.0663–0.3617, (P = .0041)]. Our findings suggest that interleukin 8 might be an important indicator of inflammatory status in both mothers and newborns. Moreover, excessive gestational weight gain was associated with an increase in birth weight.
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spelling pubmed-78702102021-02-10 Systemic inflammatory status – a bridge between gestational weight gain and neonatal outcomes (STROBE-compliant article) Rugină, Cosmin Mărginean, Cristina Oana Meliţ, Lorena Elena Huţanu, Adina Ghiga, Dana Valentina Modi, Viviana Mărginean, Claudiu Medicine (Baltimore) 5600 Pregnant women with excessive gestational weight gain express an inflammatory status with multiple negative effects on birth outcomes. The aim of this study was to identify the relationship between gestational weight gain at different gestational ages and inflammatory status in pregnant women and their newborns assessing both interleukin 6 and 8, as well as hepcidin in these couples. Our study included 170 pregnant women and their newborns. Pregnant women were clinically assessed at the end of the 1(st) trimester and at term, whereas the newborns were assessed over the first 3 days of life. The levels of interleukin 6, 8 and hepcidin were measured in both pregnant women and their newborns. We noticed higher levels of interleukin 6, interleukin 8 and hepcidin in pregnant women at the time of delivery as compared to the end of the 1st trimester. We observed a direct significant correlation between gestational weight gain at the time of delivery and interleukin 8 in both mothers [r = 0.1834, 95% CI: 0.0293–0.3290, (P = .0167)] and newborns [r = 0.1790, 95% CI: 0.0248–0.3249, (P = .0195)]. Our study underlined that a higher gestational weight gain resulted in a significantly higher birth weight [r = 0.2190, 95% CI: 0.0663–0.3617, (P = .0041)]. Our findings suggest that interleukin 8 might be an important indicator of inflammatory status in both mothers and newborns. Moreover, excessive gestational weight gain was associated with an increase in birth weight. Lippincott Williams & Wilkins 2021-02-05 /pmc/articles/PMC7870210/ /pubmed/33592904 http://dx.doi.org/10.1097/MD.0000000000024511 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5600
Rugină, Cosmin
Mărginean, Cristina Oana
Meliţ, Lorena Elena
Huţanu, Adina
Ghiga, Dana Valentina
Modi, Viviana
Mărginean, Claudiu
Systemic inflammatory status – a bridge between gestational weight gain and neonatal outcomes (STROBE-compliant article)
title Systemic inflammatory status – a bridge between gestational weight gain and neonatal outcomes (STROBE-compliant article)
title_full Systemic inflammatory status – a bridge between gestational weight gain and neonatal outcomes (STROBE-compliant article)
title_fullStr Systemic inflammatory status – a bridge between gestational weight gain and neonatal outcomes (STROBE-compliant article)
title_full_unstemmed Systemic inflammatory status – a bridge between gestational weight gain and neonatal outcomes (STROBE-compliant article)
title_short Systemic inflammatory status – a bridge between gestational weight gain and neonatal outcomes (STROBE-compliant article)
title_sort systemic inflammatory status – a bridge between gestational weight gain and neonatal outcomes (strobe-compliant article)
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870210/
https://www.ncbi.nlm.nih.gov/pubmed/33592904
http://dx.doi.org/10.1097/MD.0000000000024511
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