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Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study
Coronavirus disease 2019 (COVID-19) becomes a global pandemic in 2020. Early identification of severe ill patients is a top priority for clinicians. We aimed to describe clinical features and risk factors of severe-critically ill patients with COVID-19 in Jiangsu Province. This multi-centered retros...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870254/ https://www.ncbi.nlm.nih.gov/pubmed/33592878 http://dx.doi.org/10.1097/MD.0000000000024332 |
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author | Zhao, Jiangnan Zhu, Meiying Su, Xin Huang, Mao Yang, Yi Huang, Jianan Songshi, Ni Cao, Quan Gu, Qin Li, Jun Li, Jiashu Zhao, Wenjing Shi, Bin Shi, Yi |
author_facet | Zhao, Jiangnan Zhu, Meiying Su, Xin Huang, Mao Yang, Yi Huang, Jianan Songshi, Ni Cao, Quan Gu, Qin Li, Jun Li, Jiashu Zhao, Wenjing Shi, Bin Shi, Yi |
author_sort | Zhao, Jiangnan |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) becomes a global pandemic in 2020. Early identification of severe ill patients is a top priority for clinicians. We aimed to describe clinical features and risk factors of severe-critically ill patients with COVID-19 in Jiangsu Province. This multi-centered retrospective study collected the information of 631 laboratory-confirmed COVID-19 patients hospitalized at 28 authorized hospitals in Jiangsu province from January 23, 2019 to March 13, 2020. A total of 583 adult patients with laboratory-confirmed COVID-19 were enrolled for final analysis, including 84 severe-critically ill patients and 499 mild-moderate patients. Median age of the severe-critically ill patients was 57.0 years old (interquartile range, 49.0–65.8), and 50 (59.5%) were males. Multisystemic laboratory abnormalities were observed on admission for severe-critically ill patients. These patients showed more noticeable radiologic abnormalities and more coexisting health issues as compared to the mild-moderate patients. Most of the severe-critically ill COVID-19 patients became deteriorated in 2 weeks after diagnosis. Age, D-dimer, and lymphocytes were independently associated with the progression of severe-critically illness. Older age, higher D-dimer levels and less lymphocyte counts on admission are potential risk factors for COVID-19 patients to develop into severe and critically illness. |
format | Online Article Text |
id | pubmed-7870254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-78702542021-02-10 Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study Zhao, Jiangnan Zhu, Meiying Su, Xin Huang, Mao Yang, Yi Huang, Jianan Songshi, Ni Cao, Quan Gu, Qin Li, Jun Li, Jiashu Zhao, Wenjing Shi, Bin Shi, Yi Medicine (Baltimore) 4900 Coronavirus disease 2019 (COVID-19) becomes a global pandemic in 2020. Early identification of severe ill patients is a top priority for clinicians. We aimed to describe clinical features and risk factors of severe-critically ill patients with COVID-19 in Jiangsu Province. This multi-centered retrospective study collected the information of 631 laboratory-confirmed COVID-19 patients hospitalized at 28 authorized hospitals in Jiangsu province from January 23, 2019 to March 13, 2020. A total of 583 adult patients with laboratory-confirmed COVID-19 were enrolled for final analysis, including 84 severe-critically ill patients and 499 mild-moderate patients. Median age of the severe-critically ill patients was 57.0 years old (interquartile range, 49.0–65.8), and 50 (59.5%) were males. Multisystemic laboratory abnormalities were observed on admission for severe-critically ill patients. These patients showed more noticeable radiologic abnormalities and more coexisting health issues as compared to the mild-moderate patients. Most of the severe-critically ill COVID-19 patients became deteriorated in 2 weeks after diagnosis. Age, D-dimer, and lymphocytes were independently associated with the progression of severe-critically illness. Older age, higher D-dimer levels and less lymphocyte counts on admission are potential risk factors for COVID-19 patients to develop into severe and critically illness. Lippincott Williams & Wilkins 2021-02-05 /pmc/articles/PMC7870254/ /pubmed/33592878 http://dx.doi.org/10.1097/MD.0000000000024332 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 4900 Zhao, Jiangnan Zhu, Meiying Su, Xin Huang, Mao Yang, Yi Huang, Jianan Songshi, Ni Cao, Quan Gu, Qin Li, Jun Li, Jiashu Zhao, Wenjing Shi, Bin Shi, Yi Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study |
title | Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study |
title_full | Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study |
title_fullStr | Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study |
title_full_unstemmed | Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study |
title_short | Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study |
title_sort | clinical features and risk factors for severe-critically ill covid-19 adult patients in jiangsu, china: a multiple-centered, retrospective study |
topic | 4900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870254/ https://www.ncbi.nlm.nih.gov/pubmed/33592878 http://dx.doi.org/10.1097/MD.0000000000024332 |
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