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Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study

Coronavirus disease 2019 (COVID-19) becomes a global pandemic in 2020. Early identification of severe ill patients is a top priority for clinicians. We aimed to describe clinical features and risk factors of severe-critically ill patients with COVID-19 in Jiangsu Province. This multi-centered retros...

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Autores principales: Zhao, Jiangnan, Zhu, Meiying, Su, Xin, Huang, Mao, Yang, Yi, Huang, Jianan, Songshi, Ni, Cao, Quan, Gu, Qin, Li, Jun, Li, Jiashu, Zhao, Wenjing, Shi, Bin, Shi, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870254/
https://www.ncbi.nlm.nih.gov/pubmed/33592878
http://dx.doi.org/10.1097/MD.0000000000024332
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author Zhao, Jiangnan
Zhu, Meiying
Su, Xin
Huang, Mao
Yang, Yi
Huang, Jianan
Songshi, Ni
Cao, Quan
Gu, Qin
Li, Jun
Li, Jiashu
Zhao, Wenjing
Shi, Bin
Shi, Yi
author_facet Zhao, Jiangnan
Zhu, Meiying
Su, Xin
Huang, Mao
Yang, Yi
Huang, Jianan
Songshi, Ni
Cao, Quan
Gu, Qin
Li, Jun
Li, Jiashu
Zhao, Wenjing
Shi, Bin
Shi, Yi
author_sort Zhao, Jiangnan
collection PubMed
description Coronavirus disease 2019 (COVID-19) becomes a global pandemic in 2020. Early identification of severe ill patients is a top priority for clinicians. We aimed to describe clinical features and risk factors of severe-critically ill patients with COVID-19 in Jiangsu Province. This multi-centered retrospective study collected the information of 631 laboratory-confirmed COVID-19 patients hospitalized at 28 authorized hospitals in Jiangsu province from January 23, 2019 to March 13, 2020. A total of 583 adult patients with laboratory-confirmed COVID-19 were enrolled for final analysis, including 84 severe-critically ill patients and 499 mild-moderate patients. Median age of the severe-critically ill patients was 57.0 years old (interquartile range, 49.0–65.8), and 50 (59.5%) were males. Multisystemic laboratory abnormalities were observed on admission for severe-critically ill patients. These patients showed more noticeable radiologic abnormalities and more coexisting health issues as compared to the mild-moderate patients. Most of the severe-critically ill COVID-19 patients became deteriorated in 2 weeks after diagnosis. Age, D-dimer, and lymphocytes were independently associated with the progression of severe-critically illness. Older age, higher D-dimer levels and less lymphocyte counts on admission are potential risk factors for COVID-19 patients to develop into severe and critically illness.
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spelling pubmed-78702542021-02-10 Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study Zhao, Jiangnan Zhu, Meiying Su, Xin Huang, Mao Yang, Yi Huang, Jianan Songshi, Ni Cao, Quan Gu, Qin Li, Jun Li, Jiashu Zhao, Wenjing Shi, Bin Shi, Yi Medicine (Baltimore) 4900 Coronavirus disease 2019 (COVID-19) becomes a global pandemic in 2020. Early identification of severe ill patients is a top priority for clinicians. We aimed to describe clinical features and risk factors of severe-critically ill patients with COVID-19 in Jiangsu Province. This multi-centered retrospective study collected the information of 631 laboratory-confirmed COVID-19 patients hospitalized at 28 authorized hospitals in Jiangsu province from January 23, 2019 to March 13, 2020. A total of 583 adult patients with laboratory-confirmed COVID-19 were enrolled for final analysis, including 84 severe-critically ill patients and 499 mild-moderate patients. Median age of the severe-critically ill patients was 57.0 years old (interquartile range, 49.0–65.8), and 50 (59.5%) were males. Multisystemic laboratory abnormalities were observed on admission for severe-critically ill patients. These patients showed more noticeable radiologic abnormalities and more coexisting health issues as compared to the mild-moderate patients. Most of the severe-critically ill COVID-19 patients became deteriorated in 2 weeks after diagnosis. Age, D-dimer, and lymphocytes were independently associated with the progression of severe-critically illness. Older age, higher D-dimer levels and less lymphocyte counts on admission are potential risk factors for COVID-19 patients to develop into severe and critically illness. Lippincott Williams & Wilkins 2021-02-05 /pmc/articles/PMC7870254/ /pubmed/33592878 http://dx.doi.org/10.1097/MD.0000000000024332 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 4900
Zhao, Jiangnan
Zhu, Meiying
Su, Xin
Huang, Mao
Yang, Yi
Huang, Jianan
Songshi, Ni
Cao, Quan
Gu, Qin
Li, Jun
Li, Jiashu
Zhao, Wenjing
Shi, Bin
Shi, Yi
Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study
title Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study
title_full Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study
title_fullStr Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study
title_full_unstemmed Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study
title_short Clinical features and risk factors for severe-critically ill COVID-19 adult patients in Jiangsu, China: A multiple-centered, retrospective study
title_sort clinical features and risk factors for severe-critically ill covid-19 adult patients in jiangsu, china: a multiple-centered, retrospective study
topic 4900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870254/
https://www.ncbi.nlm.nih.gov/pubmed/33592878
http://dx.doi.org/10.1097/MD.0000000000024332
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