Cargando…

Is Qi Fu Yin effective in clinical treatment of dementia?: A meta-analysis of 697 patients

BACKGROUND: Dementia, a kind of acquired and progressive intelligence-damaging syndrome, is induced by cerebral dysfunction. Ancient records show that Qi Fu Yin (QFY) has the advantages in age-related dementia treatment. This study aims to evaluate therapeutic efficacy of QFY on dementia through met...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Lei, Qiao, Pengli, Yue, Lulu, Sun, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870270/
https://www.ncbi.nlm.nih.gov/pubmed/33592906
http://dx.doi.org/10.1097/MD.0000000000024526
_version_ 1783648785329553408
author Wang, Lei
Qiao, Pengli
Yue, Lulu
Sun, Rong
author_facet Wang, Lei
Qiao, Pengli
Yue, Lulu
Sun, Rong
author_sort Wang, Lei
collection PubMed
description BACKGROUND: Dementia, a kind of acquired and progressive intelligence-damaging syndrome, is induced by cerebral dysfunction. Ancient records show that Qi Fu Yin (QFY) has the advantages in age-related dementia treatment. This study aims to evaluate therapeutic efficacy of QFY on dementia through meta-analysis. METHODS: We comprehensively reviewed articles from various databases, including China National Knowledge Infrastructure (CNKI), Wanfang, VIP, Chinese Biomedical Literature (CBM), PubMed, and Web of Science published before June 2020, for all randomized controlled trials (RCTs) on dementia treatment with QFY. Then, we selected eligible literatures, extracted related data, and assessed risk of bias. Forest plots of total clinical effective rate, MMSE score, HDS score and ADL score illustrated the difference between the experimental group (treatment with QFY alone or combined with routine western medicine) and the control group (treatment with routine western medicine only). Random effects model and fixed effects model were adopted. Finally, publication bias was further analyzed using funnel plot, sensitivity analysis, Begg and Egger test. RESULTS: Finally, 9 RCTs, involving 697 patients, were included in this study. The results revealed that the total clinical effective rate of the experimental group was obviously higher than that of the control group (OR = 0.33, 95% CI [0.22, 0.50], P < .001). In comparison with the control group, the experimental group showed higher MMSE score (WMD = 2.60, 95% CI [2.16, 3.03], P < .001) and HDS score (WMD = 1.51, 95%CI [1.10, 1.92], P < .001). Due to few included studies, there were no statistically significance between experimental and control groups (WMD = -9.90, 95%CI [−26.09, 6.30], P = .231) regarding ADL score. In addition, there is no publication bias towards clinical effective rate and MMDE score. CONCLUSIONS: QFY only or combined with western medicine therapy can significantly improve cognitive ability compared with only western medicine therapy in dementia. However, multiple samples, RCTs of high quality are still needed to verify our conclusions.
format Online
Article
Text
id pubmed-7870270
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-78702702021-02-10 Is Qi Fu Yin effective in clinical treatment of dementia?: A meta-analysis of 697 patients Wang, Lei Qiao, Pengli Yue, Lulu Sun, Rong Medicine (Baltimore) 5300 BACKGROUND: Dementia, a kind of acquired and progressive intelligence-damaging syndrome, is induced by cerebral dysfunction. Ancient records show that Qi Fu Yin (QFY) has the advantages in age-related dementia treatment. This study aims to evaluate therapeutic efficacy of QFY on dementia through meta-analysis. METHODS: We comprehensively reviewed articles from various databases, including China National Knowledge Infrastructure (CNKI), Wanfang, VIP, Chinese Biomedical Literature (CBM), PubMed, and Web of Science published before June 2020, for all randomized controlled trials (RCTs) on dementia treatment with QFY. Then, we selected eligible literatures, extracted related data, and assessed risk of bias. Forest plots of total clinical effective rate, MMSE score, HDS score and ADL score illustrated the difference between the experimental group (treatment with QFY alone or combined with routine western medicine) and the control group (treatment with routine western medicine only). Random effects model and fixed effects model were adopted. Finally, publication bias was further analyzed using funnel plot, sensitivity analysis, Begg and Egger test. RESULTS: Finally, 9 RCTs, involving 697 patients, were included in this study. The results revealed that the total clinical effective rate of the experimental group was obviously higher than that of the control group (OR = 0.33, 95% CI [0.22, 0.50], P < .001). In comparison with the control group, the experimental group showed higher MMSE score (WMD = 2.60, 95% CI [2.16, 3.03], P < .001) and HDS score (WMD = 1.51, 95%CI [1.10, 1.92], P < .001). Due to few included studies, there were no statistically significance between experimental and control groups (WMD = -9.90, 95%CI [−26.09, 6.30], P = .231) regarding ADL score. In addition, there is no publication bias towards clinical effective rate and MMDE score. CONCLUSIONS: QFY only or combined with western medicine therapy can significantly improve cognitive ability compared with only western medicine therapy in dementia. However, multiple samples, RCTs of high quality are still needed to verify our conclusions. Lippincott Williams & Wilkins 2021-02-05 /pmc/articles/PMC7870270/ /pubmed/33592906 http://dx.doi.org/10.1097/MD.0000000000024526 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5300
Wang, Lei
Qiao, Pengli
Yue, Lulu
Sun, Rong
Is Qi Fu Yin effective in clinical treatment of dementia?: A meta-analysis of 697 patients
title Is Qi Fu Yin effective in clinical treatment of dementia?: A meta-analysis of 697 patients
title_full Is Qi Fu Yin effective in clinical treatment of dementia?: A meta-analysis of 697 patients
title_fullStr Is Qi Fu Yin effective in clinical treatment of dementia?: A meta-analysis of 697 patients
title_full_unstemmed Is Qi Fu Yin effective in clinical treatment of dementia?: A meta-analysis of 697 patients
title_short Is Qi Fu Yin effective in clinical treatment of dementia?: A meta-analysis of 697 patients
title_sort is qi fu yin effective in clinical treatment of dementia?: a meta-analysis of 697 patients
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870270/
https://www.ncbi.nlm.nih.gov/pubmed/33592906
http://dx.doi.org/10.1097/MD.0000000000024526
work_keys_str_mv AT wanglei isqifuyineffectiveinclinicaltreatmentofdementiaametaanalysisof697patients
AT qiaopengli isqifuyineffectiveinclinicaltreatmentofdementiaametaanalysisof697patients
AT yuelulu isqifuyineffectiveinclinicaltreatmentofdementiaametaanalysisof697patients
AT sunrong isqifuyineffectiveinclinicaltreatmentofdementiaametaanalysisof697patients