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Predictors of serious outcomes among patients with anaphylaxis seen in the Philippine national tertiary hospital

BACKGROUND: Anaphylaxis is a severe and life-threatening systemic hypersensitivity reaction. The incidence of anaphylaxis has increased significantly in recent years. OBJECTIVE: To identify predictors of serious outcomes among patients with anaphylaxis seen in the national tertiary hospital of the P...

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Autores principales: Tan-Lim, Carol Stephanie C., Castor, Mary Anne R., Recto, Marysia Stella T., Casis-Hao, Roxanne J., Nano, Aimee Lou M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870375/
https://www.ncbi.nlm.nih.gov/pubmed/33604278
http://dx.doi.org/10.5415/apallergy.2021.11.e8
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author Tan-Lim, Carol Stephanie C.
Castor, Mary Anne R.
Recto, Marysia Stella T.
Casis-Hao, Roxanne J.
Nano, Aimee Lou M.
author_facet Tan-Lim, Carol Stephanie C.
Castor, Mary Anne R.
Recto, Marysia Stella T.
Casis-Hao, Roxanne J.
Nano, Aimee Lou M.
author_sort Tan-Lim, Carol Stephanie C.
collection PubMed
description BACKGROUND: Anaphylaxis is a severe and life-threatening systemic hypersensitivity reaction. The incidence of anaphylaxis has increased significantly in recent years. OBJECTIVE: To identify predictors of serious outcomes among patients with anaphylaxis seen in the national tertiary hospital of the Philippines from 2015 to 2019. METHODS: Data was collected retrospectively through search of the medical records section and census reports on all patients diagnosed with anaphylaxis seen at the national tertiary hospital from 2015 to 2019. The patients’ clinical profile, management, and outcome were extracted. Multiple logistic regression analysis was used to determine the association of clinical characteristics and physicians’ management with the development of serious outcomes. Variable selection procedure through backward elimination method was used to determine significant predictors of serious outcomes of anaphylaxis. Data analysis was done using Stata 14 software. RESULTS: There were 300 patients with anaphylaxis seen at the Philippine national tertiary hospital from 2015 to 2019. Of the 300 patients, 179 were female (57.9%). The median age of the patients was 26 years old, with an interquartile range of 33 years. Only 75 patients (25%) had a past history of allergic disease. Majority of the patients (70%) had comorbidities. Drugs were the most common trigger of anaphylaxis (81.3%). Antibiotics were the most common type of drugs implicated (27%). Serious outcomes were noted in a total of 31 patients (10.3%). The significant predictors of serious outcomes in anaphylaxis are age (p = 0.034) and cofactors including use of beta-blockers and presence of acute infection (p < 0.001). CONCLUSION: In the Philippine national tertiary hospital, the incidence of anaphylaxis increased by 240% in the past decade. Predictors of serious outcome in anaphylaxis include increased age and presence of cofactors such as beta-blocker use and presence of acute infection.
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spelling pubmed-78703752021-02-17 Predictors of serious outcomes among patients with anaphylaxis seen in the Philippine national tertiary hospital Tan-Lim, Carol Stephanie C. Castor, Mary Anne R. Recto, Marysia Stella T. Casis-Hao, Roxanne J. Nano, Aimee Lou M. Asia Pac Allergy Original Article BACKGROUND: Anaphylaxis is a severe and life-threatening systemic hypersensitivity reaction. The incidence of anaphylaxis has increased significantly in recent years. OBJECTIVE: To identify predictors of serious outcomes among patients with anaphylaxis seen in the national tertiary hospital of the Philippines from 2015 to 2019. METHODS: Data was collected retrospectively through search of the medical records section and census reports on all patients diagnosed with anaphylaxis seen at the national tertiary hospital from 2015 to 2019. The patients’ clinical profile, management, and outcome were extracted. Multiple logistic regression analysis was used to determine the association of clinical characteristics and physicians’ management with the development of serious outcomes. Variable selection procedure through backward elimination method was used to determine significant predictors of serious outcomes of anaphylaxis. Data analysis was done using Stata 14 software. RESULTS: There were 300 patients with anaphylaxis seen at the Philippine national tertiary hospital from 2015 to 2019. Of the 300 patients, 179 were female (57.9%). The median age of the patients was 26 years old, with an interquartile range of 33 years. Only 75 patients (25%) had a past history of allergic disease. Majority of the patients (70%) had comorbidities. Drugs were the most common trigger of anaphylaxis (81.3%). Antibiotics were the most common type of drugs implicated (27%). Serious outcomes were noted in a total of 31 patients (10.3%). The significant predictors of serious outcomes in anaphylaxis are age (p = 0.034) and cofactors including use of beta-blockers and presence of acute infection (p < 0.001). CONCLUSION: In the Philippine national tertiary hospital, the incidence of anaphylaxis increased by 240% in the past decade. Predictors of serious outcome in anaphylaxis include increased age and presence of cofactors such as beta-blocker use and presence of acute infection. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2021-01-26 /pmc/articles/PMC7870375/ /pubmed/33604278 http://dx.doi.org/10.5415/apallergy.2021.11.e8 Text en Copyright © 2021. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Tan-Lim, Carol Stephanie C.
Castor, Mary Anne R.
Recto, Marysia Stella T.
Casis-Hao, Roxanne J.
Nano, Aimee Lou M.
Predictors of serious outcomes among patients with anaphylaxis seen in the Philippine national tertiary hospital
title Predictors of serious outcomes among patients with anaphylaxis seen in the Philippine national tertiary hospital
title_full Predictors of serious outcomes among patients with anaphylaxis seen in the Philippine national tertiary hospital
title_fullStr Predictors of serious outcomes among patients with anaphylaxis seen in the Philippine national tertiary hospital
title_full_unstemmed Predictors of serious outcomes among patients with anaphylaxis seen in the Philippine national tertiary hospital
title_short Predictors of serious outcomes among patients with anaphylaxis seen in the Philippine national tertiary hospital
title_sort predictors of serious outcomes among patients with anaphylaxis seen in the philippine national tertiary hospital
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870375/
https://www.ncbi.nlm.nih.gov/pubmed/33604278
http://dx.doi.org/10.5415/apallergy.2021.11.e8
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