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Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system
G protein-coupled receptor (GPR) 37 and GPR37L1 are known to modulate the dopaminergic neuron activity, and recently, they are identified as candidate prosaposin receptors. Intercellular prosaposin is proteolytically processed into four saposins, each of which acts as a sphingolipid hydrolase activa...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Society of Veterinary Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870391/ https://www.ncbi.nlm.nih.gov/pubmed/33208571 http://dx.doi.org/10.1292/jvms.20-0603 |
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author | SARKAR, Sonjoy HOMMA, Takeshi ONOUCHI, Sawa SHIMIZU, Yasutake SHIINA, Takahiko NABEKA, Hiroaki MATSUDA, Seiji SAITO, Shouichiro |
author_facet | SARKAR, Sonjoy HOMMA, Takeshi ONOUCHI, Sawa SHIMIZU, Yasutake SHIINA, Takahiko NABEKA, Hiroaki MATSUDA, Seiji SAITO, Shouichiro |
author_sort | SARKAR, Sonjoy |
collection | PubMed |
description | G protein-coupled receptor (GPR) 37 and GPR37L1 are known to modulate the dopaminergic neuron activity, and recently, they are identified as candidate prosaposin receptors. Intercellular prosaposin is proteolytically processed into four saposins, each of which acts as a sphingolipid hydrolase activator in the lysosome. In contrast, extracellular prosaposin exerts a trophic effect on neurons via GPR37 and GPR37L1. In this study, the expression patterns of GPR37 and GPR37L1 in the mouse digestive system were examined immunohistochemically. The islets of Langerhans of the pancreas showed intense immunoreactivity for GPR37 and GPR37L1. Weak immunoreactivity for GPR37 and GPR37L1 was found in the nerve plexuses of the esophagus and small and large intestines. Colocalization of GPR37 and tyrosine hydroxylase immunoreactivity was observed in the neuron of the nerve plexus of the large intestine. This study suggests the possibility that prosaposin affects the function of islet-secreting cells. Also, the expression of GPR37 and GPR37L1 in the nerve plexus suggests that prosaposin exerts a trophic effect not only in the central nervous system, but also in the enteric nervous system. |
format | Online Article Text |
id | pubmed-7870391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-78703912021-02-11 Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system SARKAR, Sonjoy HOMMA, Takeshi ONOUCHI, Sawa SHIMIZU, Yasutake SHIINA, Takahiko NABEKA, Hiroaki MATSUDA, Seiji SAITO, Shouichiro J Vet Med Sci Anatomy G protein-coupled receptor (GPR) 37 and GPR37L1 are known to modulate the dopaminergic neuron activity, and recently, they are identified as candidate prosaposin receptors. Intercellular prosaposin is proteolytically processed into four saposins, each of which acts as a sphingolipid hydrolase activator in the lysosome. In contrast, extracellular prosaposin exerts a trophic effect on neurons via GPR37 and GPR37L1. In this study, the expression patterns of GPR37 and GPR37L1 in the mouse digestive system were examined immunohistochemically. The islets of Langerhans of the pancreas showed intense immunoreactivity for GPR37 and GPR37L1. Weak immunoreactivity for GPR37 and GPR37L1 was found in the nerve plexuses of the esophagus and small and large intestines. Colocalization of GPR37 and tyrosine hydroxylase immunoreactivity was observed in the neuron of the nerve plexus of the large intestine. This study suggests the possibility that prosaposin affects the function of islet-secreting cells. Also, the expression of GPR37 and GPR37L1 in the nerve plexus suggests that prosaposin exerts a trophic effect not only in the central nervous system, but also in the enteric nervous system. The Japanese Society of Veterinary Science 2020-11-18 2021-01 /pmc/articles/PMC7870391/ /pubmed/33208571 http://dx.doi.org/10.1292/jvms.20-0603 Text en ©2021 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Anatomy SARKAR, Sonjoy HOMMA, Takeshi ONOUCHI, Sawa SHIMIZU, Yasutake SHIINA, Takahiko NABEKA, Hiroaki MATSUDA, Seiji SAITO, Shouichiro Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system |
title | Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system |
title_full | Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system |
title_fullStr | Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system |
title_full_unstemmed | Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system |
title_short | Expression of the G protein-coupled receptor (GPR) 37 and GPR37L1 in the mouse digestive system |
title_sort | expression of the g protein-coupled receptor (gpr) 37 and gpr37l1 in the mouse digestive system |
topic | Anatomy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870391/ https://www.ncbi.nlm.nih.gov/pubmed/33208571 http://dx.doi.org/10.1292/jvms.20-0603 |
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