Antifungal drugs-low-susceptibility in Aspergillus flavus isolated from a captively reared Okinawa rail (Hypotaenidia okinawae)

A four-month old female Okinawa rail (Hypotaenidia okinawae) presented with respiratory distress. Despite antifungal treatment with voriconazole (VRZ), micafungin (MCF), and itraconazole (ITZ), respiratory distress did not improve and the bird died 167 days after initiating treatment. Necropsy revea...

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Autores principales: KANO, Rui, TSUNOI, Meika, NAKAYA, Yumiko, NAGAMINE, Takashi, ONO, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2020
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870398/
https://www.ncbi.nlm.nih.gov/pubmed/33191334
http://dx.doi.org/10.1292/jvms.20-0380
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author KANO, Rui
TSUNOI, Meika
NAKAYA, Yumiko
NAGAMINE, Takashi
ONO, Koji
author_facet KANO, Rui
TSUNOI, Meika
NAKAYA, Yumiko
NAGAMINE, Takashi
ONO, Koji
author_sort KANO, Rui
collection PubMed
description A four-month old female Okinawa rail (Hypotaenidia okinawae) presented with respiratory distress. Despite antifungal treatment with voriconazole (VRZ), micafungin (MCF), and itraconazole (ITZ), respiratory distress did not improve and the bird died 167 days after initiating treatment. Necropsy revealed multifocal pyogranulomatous necrotic nodular lesions with numerous whitish-green fungal hyphae in the left air sac. Aspergillus flavus was isolated from the left air sac lesion. Antifungal susceptibility tests indicated that the isolate showed low susceptibility to amphotericin B (AMB), fluconazole (FLZ), VRZ and MCF.
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spelling pubmed-78703982021-02-11 Antifungal drugs-low-susceptibility in Aspergillus flavus isolated from a captively reared Okinawa rail (Hypotaenidia okinawae) KANO, Rui TSUNOI, Meika NAKAYA, Yumiko NAGAMINE, Takashi ONO, Koji J Vet Med Sci Internal Medicine A four-month old female Okinawa rail (Hypotaenidia okinawae) presented with respiratory distress. Despite antifungal treatment with voriconazole (VRZ), micafungin (MCF), and itraconazole (ITZ), respiratory distress did not improve and the bird died 167 days after initiating treatment. Necropsy revealed multifocal pyogranulomatous necrotic nodular lesions with numerous whitish-green fungal hyphae in the left air sac. Aspergillus flavus was isolated from the left air sac lesion. Antifungal susceptibility tests indicated that the isolate showed low susceptibility to amphotericin B (AMB), fluconazole (FLZ), VRZ and MCF. The Japanese Society of Veterinary Science 2020-11-13 2021-01 /pmc/articles/PMC7870398/ /pubmed/33191334 http://dx.doi.org/10.1292/jvms.20-0380 Text en ©2021 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Internal Medicine
KANO, Rui
TSUNOI, Meika
NAKAYA, Yumiko
NAGAMINE, Takashi
ONO, Koji
Antifungal drugs-low-susceptibility in Aspergillus flavus isolated from a captively reared Okinawa rail (Hypotaenidia okinawae)
title Antifungal drugs-low-susceptibility in Aspergillus flavus isolated from a captively reared Okinawa rail (Hypotaenidia okinawae)
title_full Antifungal drugs-low-susceptibility in Aspergillus flavus isolated from a captively reared Okinawa rail (Hypotaenidia okinawae)
title_fullStr Antifungal drugs-low-susceptibility in Aspergillus flavus isolated from a captively reared Okinawa rail (Hypotaenidia okinawae)
title_full_unstemmed Antifungal drugs-low-susceptibility in Aspergillus flavus isolated from a captively reared Okinawa rail (Hypotaenidia okinawae)
title_short Antifungal drugs-low-susceptibility in Aspergillus flavus isolated from a captively reared Okinawa rail (Hypotaenidia okinawae)
title_sort antifungal drugs-low-susceptibility in aspergillus flavus isolated from a captively reared okinawa rail (hypotaenidia okinawae)
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870398/
https://www.ncbi.nlm.nih.gov/pubmed/33191334
http://dx.doi.org/10.1292/jvms.20-0380
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