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Long-term administration of prednisolone: Effects on the myocardial tissue of healthy beagle dogs

This study aimed to assess the structural and functional effects of long-term hyperglucocorticoidemia on canine myocardium and compare these parameters with histopathological changes. Twelve healthy male beagle dogs were enrolled and assigned to the high-dose prednisolone (P; n=6) and control (C; n=...

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Autores principales: TANAKA, Sachiyo, SHIBUYA, Hitomi, SUZUKI, Shuji, KANNO, Nobuo, HARADA, Yasuji, SATO, Asaka, SOETA, Satoshi, HARA, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870400/
https://www.ncbi.nlm.nih.gov/pubmed/33268642
http://dx.doi.org/10.1292/jvms.20-0401
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author TANAKA, Sachiyo
SHIBUYA, Hitomi
SUZUKI, Shuji
KANNO, Nobuo
HARADA, Yasuji
SATO, Asaka
SOETA, Satoshi
HARA, Yasushi
author_facet TANAKA, Sachiyo
SHIBUYA, Hitomi
SUZUKI, Shuji
KANNO, Nobuo
HARADA, Yasuji
SATO, Asaka
SOETA, Satoshi
HARA, Yasushi
author_sort TANAKA, Sachiyo
collection PubMed
description This study aimed to assess the structural and functional effects of long-term hyperglucocorticoidemia on canine myocardium and compare these parameters with histopathological changes. Twelve healthy male beagle dogs were enrolled and assigned to the high-dose prednisolone (P; n=6) and control (C; n=6) groups. The P group was treated with 2 mg/kg of prednisolone BID for 84 days. Clinical parameters were measured using echocardiography and non-invasive systolic blood pressure (SBP) measured before the initiation of synthetic corticosteroids and at 7, 28, 56, and 84 days after the start of medication. For histological evaluation, cardiovascular tissue was harvested from dogs in groups P (at the end of the medication period) and C (scheduled to be euthanized for unrelated reasons). In the P group, clinical changes including thickening of the left ventricular free wall (LVFW) and interventricular septum (IVS), decreased left ventricular (LV) diastolic function, and increased SBP were observed after the start of medication. During histological evaluation, fibrosis was observed in the LVFW and IVS in the P group. Furthermore, decreased glucocorticoid receptor (GCR) levels were observed in the LVFW, right ventricular free wall (RVFW), and IVS and increased mineralocorticoid receptor (MCR) levels were observed in the LVFW and RVFW in the P group compared with those in the C group. In conclusion, fibrosis may cause LV structural and functional abnormalities in dogs with hyperadrenocorticism. Furthermore, GCR downregulation and upregulated MCR might influence the myocardial fibrosis.
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spelling pubmed-78704002021-02-11 Long-term administration of prednisolone: Effects on the myocardial tissue of healthy beagle dogs TANAKA, Sachiyo SHIBUYA, Hitomi SUZUKI, Shuji KANNO, Nobuo HARADA, Yasuji SATO, Asaka SOETA, Satoshi HARA, Yasushi J Vet Med Sci Internal Medicine This study aimed to assess the structural and functional effects of long-term hyperglucocorticoidemia on canine myocardium and compare these parameters with histopathological changes. Twelve healthy male beagle dogs were enrolled and assigned to the high-dose prednisolone (P; n=6) and control (C; n=6) groups. The P group was treated with 2 mg/kg of prednisolone BID for 84 days. Clinical parameters were measured using echocardiography and non-invasive systolic blood pressure (SBP) measured before the initiation of synthetic corticosteroids and at 7, 28, 56, and 84 days after the start of medication. For histological evaluation, cardiovascular tissue was harvested from dogs in groups P (at the end of the medication period) and C (scheduled to be euthanized for unrelated reasons). In the P group, clinical changes including thickening of the left ventricular free wall (LVFW) and interventricular septum (IVS), decreased left ventricular (LV) diastolic function, and increased SBP were observed after the start of medication. During histological evaluation, fibrosis was observed in the LVFW and IVS in the P group. Furthermore, decreased glucocorticoid receptor (GCR) levels were observed in the LVFW, right ventricular free wall (RVFW), and IVS and increased mineralocorticoid receptor (MCR) levels were observed in the LVFW and RVFW in the P group compared with those in the C group. In conclusion, fibrosis may cause LV structural and functional abnormalities in dogs with hyperadrenocorticism. Furthermore, GCR downregulation and upregulated MCR might influence the myocardial fibrosis. The Japanese Society of Veterinary Science 2020-12-02 2021-01 /pmc/articles/PMC7870400/ /pubmed/33268642 http://dx.doi.org/10.1292/jvms.20-0401 Text en ©2021 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Internal Medicine
TANAKA, Sachiyo
SHIBUYA, Hitomi
SUZUKI, Shuji
KANNO, Nobuo
HARADA, Yasuji
SATO, Asaka
SOETA, Satoshi
HARA, Yasushi
Long-term administration of prednisolone: Effects on the myocardial tissue of healthy beagle dogs
title Long-term administration of prednisolone: Effects on the myocardial tissue of healthy beagle dogs
title_full Long-term administration of prednisolone: Effects on the myocardial tissue of healthy beagle dogs
title_fullStr Long-term administration of prednisolone: Effects on the myocardial tissue of healthy beagle dogs
title_full_unstemmed Long-term administration of prednisolone: Effects on the myocardial tissue of healthy beagle dogs
title_short Long-term administration of prednisolone: Effects on the myocardial tissue of healthy beagle dogs
title_sort long-term administration of prednisolone: effects on the myocardial tissue of healthy beagle dogs
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870400/
https://www.ncbi.nlm.nih.gov/pubmed/33268642
http://dx.doi.org/10.1292/jvms.20-0401
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