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Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood

Deficiencies of many nutrients in pregnancy have adverse effects on fetal brain development with consequent impaired cognitive function in childhood. However, it is unclear whether deficiencies of vitamin B12 prenatally are harmful to the developing fetus. We therefore used the Avon Longitudinal Stu...

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Autores principales: Golding, Jean, Gregory, Steven, Clark, Rosie, Iles-Caven, Yasmin, Ellis, Genette, Taylor, Caroline M., Hibbeln, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870459/
https://www.ncbi.nlm.nih.gov/pubmed/33551260
http://dx.doi.org/10.1016/j.nutres.2020.12.005
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author Golding, Jean
Gregory, Steven
Clark, Rosie
Iles-Caven, Yasmin
Ellis, Genette
Taylor, Caroline M.
Hibbeln, Joseph
author_facet Golding, Jean
Gregory, Steven
Clark, Rosie
Iles-Caven, Yasmin
Ellis, Genette
Taylor, Caroline M.
Hibbeln, Joseph
author_sort Golding, Jean
collection PubMed
description Deficiencies of many nutrients in pregnancy have adverse effects on fetal brain development with consequent impaired cognitive function in childhood. However, it is unclear whether deficiencies of vitamin B12 prenatally are harmful to the developing fetus. We therefore used the Avon Longitudinal Study of Parents and Children to test the hypothesis that cognitive outcomes in childhood are reduced if their mothers consumed a diet low in vitamin B12 during pregnancy. A detailed exposome analysis was used to identify 9 factors independently associated with low vitamin B12 intake. These were taken into account in each of 26 outcome analyses. Results showed that the children of women with the lowest 10% intake of B12 were at increased risk of poor vocabulary at 24 months, reduced ability at combining words at 38 months, poor speech intelligibility at 6 years, poor mathematics comprehension at school years 4 and 6 (ages 8-9 and 10-11 years), and poor results on the national mathematics tests (age 13). There were no such significant adjusted associations for reading or spelling abilities, or for verbal or full-scale IQ (Intelligence Quotient) at 8 or at 15. Thus, we have confirmed that there are adverse effects on the child's development if the pregnant woman has a low intake of vitamin B12, and we have shown that these are specific to certain speech and mathematical abilities.
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spelling pubmed-78704592021-02-17 Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood Golding, Jean Gregory, Steven Clark, Rosie Iles-Caven, Yasmin Ellis, Genette Taylor, Caroline M. Hibbeln, Joseph Nutr Res Article Deficiencies of many nutrients in pregnancy have adverse effects on fetal brain development with consequent impaired cognitive function in childhood. However, it is unclear whether deficiencies of vitamin B12 prenatally are harmful to the developing fetus. We therefore used the Avon Longitudinal Study of Parents and Children to test the hypothesis that cognitive outcomes in childhood are reduced if their mothers consumed a diet low in vitamin B12 during pregnancy. A detailed exposome analysis was used to identify 9 factors independently associated with low vitamin B12 intake. These were taken into account in each of 26 outcome analyses. Results showed that the children of women with the lowest 10% intake of B12 were at increased risk of poor vocabulary at 24 months, reduced ability at combining words at 38 months, poor speech intelligibility at 6 years, poor mathematics comprehension at school years 4 and 6 (ages 8-9 and 10-11 years), and poor results on the national mathematics tests (age 13). There were no such significant adjusted associations for reading or spelling abilities, or for verbal or full-scale IQ (Intelligence Quotient) at 8 or at 15. Thus, we have confirmed that there are adverse effects on the child's development if the pregnant woman has a low intake of vitamin B12, and we have shown that these are specific to certain speech and mathematical abilities. Elsevier Science 2021-02 /pmc/articles/PMC7870459/ /pubmed/33551260 http://dx.doi.org/10.1016/j.nutres.2020.12.005 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Golding, Jean
Gregory, Steven
Clark, Rosie
Iles-Caven, Yasmin
Ellis, Genette
Taylor, Caroline M.
Hibbeln, Joseph
Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood
title Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood
title_full Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood
title_fullStr Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood
title_full_unstemmed Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood
title_short Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood
title_sort maternal prenatal vitamin b12 intake is associated with speech development and mathematical abilities in childhood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870459/
https://www.ncbi.nlm.nih.gov/pubmed/33551260
http://dx.doi.org/10.1016/j.nutres.2020.12.005
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