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General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins

Despite six decades of efforts to synthesize peptides and proteins bearing multiple disulfide bonds, this synthetic challenge remains an unsolved problem in most targets (e.g., knotted mini proteins). Here we show a de novo general synthetic strategy for the ultrafast, high-yielding formation of two...

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Detalles Bibliográficos
Autores principales: Laps, Shay, Atamleh, Fatima, Kamnesky, Guy, Sun, Hao, Brik, Ashraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870662/
https://www.ncbi.nlm.nih.gov/pubmed/33558523
http://dx.doi.org/10.1038/s41467-021-21209-0

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