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Autism Rating Scale: A New Tool for Characterizing the Schizophrenia Phenotype

Social dysfunctions (SD) are frequently observed in subjects with schizophrenia. Some of these dysfunctions are also observed in other neuropsychiatric disorders such as autism spectrum disorders (ASD), major depression, bipolar disorder, or Alzheimer disease. Recently, a characterization of a speci...

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Autores principales: Palumbo, Davide, Stanghellini, Giovanni, Mucci, Armida, Ballerini, Massimo, Giordano, Giulia Maria, Lysaker, Paul H., Galderisi, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870791/
https://www.ncbi.nlm.nih.gov/pubmed/33574776
http://dx.doi.org/10.3389/fpsyt.2021.622359
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author Palumbo, Davide
Stanghellini, Giovanni
Mucci, Armida
Ballerini, Massimo
Giordano, Giulia Maria
Lysaker, Paul H.
Galderisi, Silvana
author_facet Palumbo, Davide
Stanghellini, Giovanni
Mucci, Armida
Ballerini, Massimo
Giordano, Giulia Maria
Lysaker, Paul H.
Galderisi, Silvana
author_sort Palumbo, Davide
collection PubMed
description Social dysfunctions (SD) are frequently observed in subjects with schizophrenia. Some of these dysfunctions are also observed in other neuropsychiatric disorders such as autism spectrum disorders (ASD), major depression, bipolar disorder, or Alzheimer disease. Recently, a characterization of a specific type of SD in schizophrenia has been proposed, with the concept of dis-sociality, which form the core aspect of “Schizophrenic Autism” (SA). The present study aimed to explore the presence in people with schizophrenia of SA, independent of other autistic traits, which can be often found in schizophrenia and other neurodevelopmental disorders. We used a structured interview—the Autism Rating Scale (ARS), an instrument devised to detect and measure SA. Fifty-one outpatients affected by schizophrenia (26 remitted, SCZ-r) and 28 affected by bipolar disorder type 1, with psychotic features, in the euthymic phase (BD-e) were recruited. Before assessing the specificity for schizophrenia of SA, we tested the internal consistency, the convergent and divergent validity of the ARS in the schizophrenia sample. Specificity was assessed by examining potential differences in ARS scores between SCZ-r and BD-e subjects. ARS showed good internal consistency, as well as convergent and divergent validity. ARS items were more frequently of moderate severity in SCZ-r than in BD-e subjects. This scale can contribute to establish more precise phenomenal boundaries between schizophrenia and bipolar disorder, and opens up the possibility of identifying a different type of SD in schizophrenia, independent of autistic traits and negative symptoms, which might benefit from different treatments.
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spelling pubmed-78707912021-02-10 Autism Rating Scale: A New Tool for Characterizing the Schizophrenia Phenotype Palumbo, Davide Stanghellini, Giovanni Mucci, Armida Ballerini, Massimo Giordano, Giulia Maria Lysaker, Paul H. Galderisi, Silvana Front Psychiatry Psychiatry Social dysfunctions (SD) are frequently observed in subjects with schizophrenia. Some of these dysfunctions are also observed in other neuropsychiatric disorders such as autism spectrum disorders (ASD), major depression, bipolar disorder, or Alzheimer disease. Recently, a characterization of a specific type of SD in schizophrenia has been proposed, with the concept of dis-sociality, which form the core aspect of “Schizophrenic Autism” (SA). The present study aimed to explore the presence in people with schizophrenia of SA, independent of other autistic traits, which can be often found in schizophrenia and other neurodevelopmental disorders. We used a structured interview—the Autism Rating Scale (ARS), an instrument devised to detect and measure SA. Fifty-one outpatients affected by schizophrenia (26 remitted, SCZ-r) and 28 affected by bipolar disorder type 1, with psychotic features, in the euthymic phase (BD-e) were recruited. Before assessing the specificity for schizophrenia of SA, we tested the internal consistency, the convergent and divergent validity of the ARS in the schizophrenia sample. Specificity was assessed by examining potential differences in ARS scores between SCZ-r and BD-e subjects. ARS showed good internal consistency, as well as convergent and divergent validity. ARS items were more frequently of moderate severity in SCZ-r than in BD-e subjects. This scale can contribute to establish more precise phenomenal boundaries between schizophrenia and bipolar disorder, and opens up the possibility of identifying a different type of SD in schizophrenia, independent of autistic traits and negative symptoms, which might benefit from different treatments. Frontiers Media S.A. 2021-01-26 /pmc/articles/PMC7870791/ /pubmed/33574776 http://dx.doi.org/10.3389/fpsyt.2021.622359 Text en Copyright © 2021 Palumbo, Stanghellini, Mucci, Ballerini, Giordano, Lysaker and Galderisi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Palumbo, Davide
Stanghellini, Giovanni
Mucci, Armida
Ballerini, Massimo
Giordano, Giulia Maria
Lysaker, Paul H.
Galderisi, Silvana
Autism Rating Scale: A New Tool for Characterizing the Schizophrenia Phenotype
title Autism Rating Scale: A New Tool for Characterizing the Schizophrenia Phenotype
title_full Autism Rating Scale: A New Tool for Characterizing the Schizophrenia Phenotype
title_fullStr Autism Rating Scale: A New Tool for Characterizing the Schizophrenia Phenotype
title_full_unstemmed Autism Rating Scale: A New Tool for Characterizing the Schizophrenia Phenotype
title_short Autism Rating Scale: A New Tool for Characterizing the Schizophrenia Phenotype
title_sort autism rating scale: a new tool for characterizing the schizophrenia phenotype
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870791/
https://www.ncbi.nlm.nih.gov/pubmed/33574776
http://dx.doi.org/10.3389/fpsyt.2021.622359
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