Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis

Systemic AL amyloidosis is a debilitating and potentially fatal disease that arises from the misfolding and fibrillation of immunoglobulin light chains (LCs). The disease is patient-specific with essentially each patient possessing a unique LC sequence. In this study, we present two ex vivo fibril s...

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Detalles Bibliográficos
Autores principales: Radamaker, Lynn, Baur, Julian, Huhn, Stefanie, Haupt, Christian, Hegenbart, Ute, Schönland, Stefan, Bansal, Akanksha, Schmidt, Matthias, Fändrich, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870857/
https://www.ncbi.nlm.nih.gov/pubmed/33558536
http://dx.doi.org/10.1038/s41467-021-21126-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870857/
https://www.ncbi.nlm.nih.gov/pubmed/33558536
http://dx.doi.org/10.1038/s41467-021-21126-2

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