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Self-Nucleic Acid Sensing: A Novel Crucial Pathway Involved in Obesity-Mediated Metaflammation and Metabolic Syndrome

Obesity and overweight are a global health problem affecting almost one third of the world population. There are multiple complications associated with obesity including metabolic syndrome that commonly lead to development of type II diabetes and non-alcoholic fatty liver disease. The development of...

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Autores principales: Ferriere, Amandine, Santa, Pauline, Garreau, Anne, Bandopadhyay, Purbita, Blanco, Patrick, Ganguly, Dipyaman, Sisirak, Vanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870860/
https://www.ncbi.nlm.nih.gov/pubmed/33574823
http://dx.doi.org/10.3389/fimmu.2020.624256
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author Ferriere, Amandine
Santa, Pauline
Garreau, Anne
Bandopadhyay, Purbita
Blanco, Patrick
Ganguly, Dipyaman
Sisirak, Vanja
author_facet Ferriere, Amandine
Santa, Pauline
Garreau, Anne
Bandopadhyay, Purbita
Blanco, Patrick
Ganguly, Dipyaman
Sisirak, Vanja
author_sort Ferriere, Amandine
collection PubMed
description Obesity and overweight are a global health problem affecting almost one third of the world population. There are multiple complications associated with obesity including metabolic syndrome that commonly lead to development of type II diabetes and non-alcoholic fatty liver disease. The development of metabolic syndrome and severe complications associated with obesity is attributed to the chronic low-grade inflammation that occurs in metabolic tissues such as the liver and the white adipose tissue. In recent years, nucleic acids (mostly DNA), which accumulate systemically in obese individuals, were shown to aberrantly activate innate immune responses and thus to contribute to metabolic tissue inflammation. This minireview will focus on (i) the main sources and forms of nucleic acids that accumulate during obesity, (ii) the sensing pathways required for their detection, and (iii) the key cellular players involved in this process. Fully elucidating the role of nucleic acids in the induction of inflammation induced by obesity would promote the identification of new and long-awaited therapeutic approaches to limit obesity-mediated complications.
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spelling pubmed-78708602021-02-10 Self-Nucleic Acid Sensing: A Novel Crucial Pathway Involved in Obesity-Mediated Metaflammation and Metabolic Syndrome Ferriere, Amandine Santa, Pauline Garreau, Anne Bandopadhyay, Purbita Blanco, Patrick Ganguly, Dipyaman Sisirak, Vanja Front Immunol Immunology Obesity and overweight are a global health problem affecting almost one third of the world population. There are multiple complications associated with obesity including metabolic syndrome that commonly lead to development of type II diabetes and non-alcoholic fatty liver disease. The development of metabolic syndrome and severe complications associated with obesity is attributed to the chronic low-grade inflammation that occurs in metabolic tissues such as the liver and the white adipose tissue. In recent years, nucleic acids (mostly DNA), which accumulate systemically in obese individuals, were shown to aberrantly activate innate immune responses and thus to contribute to metabolic tissue inflammation. This minireview will focus on (i) the main sources and forms of nucleic acids that accumulate during obesity, (ii) the sensing pathways required for their detection, and (iii) the key cellular players involved in this process. Fully elucidating the role of nucleic acids in the induction of inflammation induced by obesity would promote the identification of new and long-awaited therapeutic approaches to limit obesity-mediated complications. Frontiers Media S.A. 2021-01-26 /pmc/articles/PMC7870860/ /pubmed/33574823 http://dx.doi.org/10.3389/fimmu.2020.624256 Text en Copyright © 2021 Ferriere, Santa, Garreau, Bandopadhyay, Blanco, Ganguly and Sisirak http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ferriere, Amandine
Santa, Pauline
Garreau, Anne
Bandopadhyay, Purbita
Blanco, Patrick
Ganguly, Dipyaman
Sisirak, Vanja
Self-Nucleic Acid Sensing: A Novel Crucial Pathway Involved in Obesity-Mediated Metaflammation and Metabolic Syndrome
title Self-Nucleic Acid Sensing: A Novel Crucial Pathway Involved in Obesity-Mediated Metaflammation and Metabolic Syndrome
title_full Self-Nucleic Acid Sensing: A Novel Crucial Pathway Involved in Obesity-Mediated Metaflammation and Metabolic Syndrome
title_fullStr Self-Nucleic Acid Sensing: A Novel Crucial Pathway Involved in Obesity-Mediated Metaflammation and Metabolic Syndrome
title_full_unstemmed Self-Nucleic Acid Sensing: A Novel Crucial Pathway Involved in Obesity-Mediated Metaflammation and Metabolic Syndrome
title_short Self-Nucleic Acid Sensing: A Novel Crucial Pathway Involved in Obesity-Mediated Metaflammation and Metabolic Syndrome
title_sort self-nucleic acid sensing: a novel crucial pathway involved in obesity-mediated metaflammation and metabolic syndrome
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870860/
https://www.ncbi.nlm.nih.gov/pubmed/33574823
http://dx.doi.org/10.3389/fimmu.2020.624256
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