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The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
The beating heart possesses the intrinsic ability to adapt cardiac output to changes in mechanical load. The century-old Frank–Starling law and Anrep effect have documented that stretching the heart during diastolic filling increases its contractile force. However, the molecular mechanotransduction...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870949/ https://www.ncbi.nlm.nih.gov/pubmed/33558521 http://dx.doi.org/10.1038/s41467-021-21178-4 |