Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells

Although tetraarsenic hexoxide is known to exert an anti-tumor effect by inducing apoptosis in various cancer cells, its effect on other forms of regulated cell death remains unclear. Here, we show that tetraarsenic hexoxide induces the pyroptotic cell death through activation of mitochondrial react...

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Detalles Bibliográficos
Autores principales: An, Haein, Heo, Jin Sun, Kim, Pyunggang, Lian, Zenglin, Lee, Siyoung, Park, Jinah, Hong, Eunji, Pang, Kyoungwha, Park, Yuna, Ooshima, Akira, Lee, Jihee, Son, Minjung, Park, Hyeyeon, Wu, Zhaoyan, Park, Kyung-Soon, Kim, Seong-Jin, Bae, Illju, Yang, Kyung-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870965/
https://www.ncbi.nlm.nih.gov/pubmed/33558527
http://dx.doi.org/10.1038/s41419-021-03454-9

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