Stunning symmetries involved in the self-assembly of the HSV-1 capsid

Herpes simplex virus-1 (HSV-1) is an enveloped dsDNA virus, infecting ~ 67% of humans. Here, we present the essential components of the HSV-1, focusing on stunning symmetries on the capsid. However, little is known about how the symmetries are involved dynamically in the self-assembly process. We su...

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Detalles Bibliográficos
Autores principales: Lee, Joo-hyeon, Shim, Jaehyu, Kim, Seung Joong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physical Society 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871024/
https://www.ncbi.nlm.nih.gov/pubmed/33584000
http://dx.doi.org/10.1007/s40042-020-00044-4
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author Lee, Joo-hyeon
Shim, Jaehyu
Kim, Seung Joong
author_facet Lee, Joo-hyeon
Shim, Jaehyu
Kim, Seung Joong
author_sort Lee, Joo-hyeon
collection PubMed
description Herpes simplex virus-1 (HSV-1) is an enveloped dsDNA virus, infecting ~ 67% of humans. Here, we present the essential components of the HSV-1, focusing on stunning symmetries on the capsid. However, little is known about how the symmetries are involved dynamically in the self-assembly process. We suggest small angle X-ray scattering as a suitable method to capture the dynamics of self-assembly. Furthermore, our understanding of the viruses can be expanded by using an integrative approach that combines heterogeneous types of data, thus promoting new diagnostic tools and a cure for viral infections.
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spelling pubmed-78710242021-02-09 Stunning symmetries involved in the self-assembly of the HSV-1 capsid Lee, Joo-hyeon Shim, Jaehyu Kim, Seung Joong J Korean Phys Soc Review Herpes simplex virus-1 (HSV-1) is an enveloped dsDNA virus, infecting ~ 67% of humans. Here, we present the essential components of the HSV-1, focusing on stunning symmetries on the capsid. However, little is known about how the symmetries are involved dynamically in the self-assembly process. We suggest small angle X-ray scattering as a suitable method to capture the dynamics of self-assembly. Furthermore, our understanding of the viruses can be expanded by using an integrative approach that combines heterogeneous types of data, thus promoting new diagnostic tools and a cure for viral infections. The Korean Physical Society 2021-02-09 2021 /pmc/articles/PMC7871024/ /pubmed/33584000 http://dx.doi.org/10.1007/s40042-020-00044-4 Text en © The Korean Physical Society 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Lee, Joo-hyeon
Shim, Jaehyu
Kim, Seung Joong
Stunning symmetries involved in the self-assembly of the HSV-1 capsid
title Stunning symmetries involved in the self-assembly of the HSV-1 capsid
title_full Stunning symmetries involved in the self-assembly of the HSV-1 capsid
title_fullStr Stunning symmetries involved in the self-assembly of the HSV-1 capsid
title_full_unstemmed Stunning symmetries involved in the self-assembly of the HSV-1 capsid
title_short Stunning symmetries involved in the self-assembly of the HSV-1 capsid
title_sort stunning symmetries involved in the self-assembly of the hsv-1 capsid
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871024/
https://www.ncbi.nlm.nih.gov/pubmed/33584000
http://dx.doi.org/10.1007/s40042-020-00044-4
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