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Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives
A continuous flow process is presented that couples a Curtius rearrangement step with a biocatalytic impurity tagging strategy to produce a series of valuable Cbz-carbamate products. Immobilized CALB was exploited as a robust hydrolase to transform residual benzyl alcohol into easily separable benzy...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871027/ https://www.ncbi.nlm.nih.gov/pubmed/33828617 http://dx.doi.org/10.3762/bjoc.17.33 |