Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database

OBJECTIVES: This study aimed to evaluate the association between the red blood cell distribution width (RDW) and mortality in patients with stroke. METHODS: We conducted a retrospective cohort study on patients with stroke in the Medical Information Mart for Intensive Care Database III. Cox proporti...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Han, Zhao, Yuanchen, Wu, Zhipeng, Cheng, Yisheng, Zhao, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871051/
https://www.ncbi.nlm.nih.gov/pubmed/33530799
http://dx.doi.org/10.1177/0300060520980587
_version_ 1783648936239562752
author Zhao, Han
Zhao, Yuanchen
Wu, Zhipeng
Cheng, Yisheng
Zhao, Na
author_facet Zhao, Han
Zhao, Yuanchen
Wu, Zhipeng
Cheng, Yisheng
Zhao, Na
author_sort Zhao, Han
collection PubMed
description OBJECTIVES: This study aimed to evaluate the association between the red blood cell distribution width (RDW) and mortality in patients with stroke. METHODS: We conducted a retrospective cohort study on patients with stroke in the Medical Information Mart for Intensive Care Database III. Cox proportional hazards regression models were used to estimate hazard ratios of 30-day, 90-day, and 1-year mortality in relation to the RDW level. RESULTS: A total of 4134 patients were enrolled, including 2646 patients with ischemic stroke and 1668 with hemorrhagic stroke. After adjustment for potential confounders, the hazard ratio (95% confidence interval) of 30-day mortality for the second (RDW: 13.4%–14.3%) and third (>14.3%) tertiles was 1.15 (0.96, 1.37) and 1.40 (1.17, 1.68), respectively, compared with the reference group (<13.4%). A two-piecewise linear regression model was established and the inflection point of RDW was 16.7%. When RDW was >16.7%, an increase in RDW did not increase stroke mortality. CONCLUSIONS: The RDW is a prognostic factor of patients with stroke. This finding needs to be confirmed in future prospective studies.
format Online
Article
Text
id pubmed-7871051
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-78710512021-02-19 Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database Zhao, Han Zhao, Yuanchen Wu, Zhipeng Cheng, Yisheng Zhao, Na J Int Med Res Retrospective Clinical Research Report OBJECTIVES: This study aimed to evaluate the association between the red blood cell distribution width (RDW) and mortality in patients with stroke. METHODS: We conducted a retrospective cohort study on patients with stroke in the Medical Information Mart for Intensive Care Database III. Cox proportional hazards regression models were used to estimate hazard ratios of 30-day, 90-day, and 1-year mortality in relation to the RDW level. RESULTS: A total of 4134 patients were enrolled, including 2646 patients with ischemic stroke and 1668 with hemorrhagic stroke. After adjustment for potential confounders, the hazard ratio (95% confidence interval) of 30-day mortality for the second (RDW: 13.4%–14.3%) and third (>14.3%) tertiles was 1.15 (0.96, 1.37) and 1.40 (1.17, 1.68), respectively, compared with the reference group (<13.4%). A two-piecewise linear regression model was established and the inflection point of RDW was 16.7%. When RDW was >16.7%, an increase in RDW did not increase stroke mortality. CONCLUSIONS: The RDW is a prognostic factor of patients with stroke. This finding needs to be confirmed in future prospective studies. SAGE Publications 2021-02-02 /pmc/articles/PMC7871051/ /pubmed/33530799 http://dx.doi.org/10.1177/0300060520980587 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Zhao, Han
Zhao, Yuanchen
Wu, Zhipeng
Cheng, Yisheng
Zhao, Na
Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database
title Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database
title_full Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database
title_fullStr Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database
title_full_unstemmed Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database
title_short Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database
title_sort red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871051/
https://www.ncbi.nlm.nih.gov/pubmed/33530799
http://dx.doi.org/10.1177/0300060520980587
work_keys_str_mv AT zhaohan redcelldistributionwidthisassociatedwithallcausemortalityinpatientswithacutestrokearetrospectiveanalysisofalargeclinicaldatabase
AT zhaoyuanchen redcelldistributionwidthisassociatedwithallcausemortalityinpatientswithacutestrokearetrospectiveanalysisofalargeclinicaldatabase
AT wuzhipeng redcelldistributionwidthisassociatedwithallcausemortalityinpatientswithacutestrokearetrospectiveanalysisofalargeclinicaldatabase
AT chengyisheng redcelldistributionwidthisassociatedwithallcausemortalityinpatientswithacutestrokearetrospectiveanalysisofalargeclinicaldatabase
AT zhaona redcelldistributionwidthisassociatedwithallcausemortalityinpatientswithacutestrokearetrospectiveanalysisofalargeclinicaldatabase