Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database
OBJECTIVES: This study aimed to evaluate the association between the red blood cell distribution width (RDW) and mortality in patients with stroke. METHODS: We conducted a retrospective cohort study on patients with stroke in the Medical Information Mart for Intensive Care Database III. Cox proporti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871051/ https://www.ncbi.nlm.nih.gov/pubmed/33530799 http://dx.doi.org/10.1177/0300060520980587 |
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author | Zhao, Han Zhao, Yuanchen Wu, Zhipeng Cheng, Yisheng Zhao, Na |
author_facet | Zhao, Han Zhao, Yuanchen Wu, Zhipeng Cheng, Yisheng Zhao, Na |
author_sort | Zhao, Han |
collection | PubMed |
description | OBJECTIVES: This study aimed to evaluate the association between the red blood cell distribution width (RDW) and mortality in patients with stroke. METHODS: We conducted a retrospective cohort study on patients with stroke in the Medical Information Mart for Intensive Care Database III. Cox proportional hazards regression models were used to estimate hazard ratios of 30-day, 90-day, and 1-year mortality in relation to the RDW level. RESULTS: A total of 4134 patients were enrolled, including 2646 patients with ischemic stroke and 1668 with hemorrhagic stroke. After adjustment for potential confounders, the hazard ratio (95% confidence interval) of 30-day mortality for the second (RDW: 13.4%–14.3%) and third (>14.3%) tertiles was 1.15 (0.96, 1.37) and 1.40 (1.17, 1.68), respectively, compared with the reference group (<13.4%). A two-piecewise linear regression model was established and the inflection point of RDW was 16.7%. When RDW was >16.7%, an increase in RDW did not increase stroke mortality. CONCLUSIONS: The RDW is a prognostic factor of patients with stroke. This finding needs to be confirmed in future prospective studies. |
format | Online Article Text |
id | pubmed-7871051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-78710512021-02-19 Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database Zhao, Han Zhao, Yuanchen Wu, Zhipeng Cheng, Yisheng Zhao, Na J Int Med Res Retrospective Clinical Research Report OBJECTIVES: This study aimed to evaluate the association between the red blood cell distribution width (RDW) and mortality in patients with stroke. METHODS: We conducted a retrospective cohort study on patients with stroke in the Medical Information Mart for Intensive Care Database III. Cox proportional hazards regression models were used to estimate hazard ratios of 30-day, 90-day, and 1-year mortality in relation to the RDW level. RESULTS: A total of 4134 patients were enrolled, including 2646 patients with ischemic stroke and 1668 with hemorrhagic stroke. After adjustment for potential confounders, the hazard ratio (95% confidence interval) of 30-day mortality for the second (RDW: 13.4%–14.3%) and third (>14.3%) tertiles was 1.15 (0.96, 1.37) and 1.40 (1.17, 1.68), respectively, compared with the reference group (<13.4%). A two-piecewise linear regression model was established and the inflection point of RDW was 16.7%. When RDW was >16.7%, an increase in RDW did not increase stroke mortality. CONCLUSIONS: The RDW is a prognostic factor of patients with stroke. This finding needs to be confirmed in future prospective studies. SAGE Publications 2021-02-02 /pmc/articles/PMC7871051/ /pubmed/33530799 http://dx.doi.org/10.1177/0300060520980587 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Retrospective Clinical Research Report Zhao, Han Zhao, Yuanchen Wu, Zhipeng Cheng, Yisheng Zhao, Na Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database |
title | Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database |
title_full | Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database |
title_fullStr | Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database |
title_full_unstemmed | Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database |
title_short | Red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database |
title_sort | red cell distribution width is associated with all-cause mortality in patients with acute stroke: a retrospective analysis of a large clinical database |
topic | Retrospective Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871051/ https://www.ncbi.nlm.nih.gov/pubmed/33530799 http://dx.doi.org/10.1177/0300060520980587 |
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