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Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report
POEMS syndrome is a rare multisystem disease associated with an underlying plasma cell disorder. Its name is an acronym for peripheral neuropathy (P), endocrinopathy (E), organomegaly (O), monoclonal plasma cell proliferative disorder (M), and skin changes (S). This case report describes a patient w...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871093/ https://www.ncbi.nlm.nih.gov/pubmed/33530791 http://dx.doi.org/10.1177/0300060520986706 |
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author | Shi, Huan Jiang, Xiaohong Wang, Long Zhou, Jiayan |
author_facet | Shi, Huan Jiang, Xiaohong Wang, Long Zhou, Jiayan |
author_sort | Shi, Huan |
collection | PubMed |
description | POEMS syndrome is a rare multisystem disease associated with an underlying plasma cell disorder. Its name is an acronym for peripheral neuropathy (P), endocrinopathy (E), organomegaly (O), monoclonal plasma cell proliferative disorder (M), and skin changes (S). This case report describes a patient with POEMS syndrome who presented with progressive fatigue and numbness in the lower extremities. Initially, the patient was erroneously diagnosed with diabetes and diabetic peripheral neuropathy because of the endocrinopathy associated with POEMS syndrome. After a second hospitalization, the patient was diagnosed with POEMS syndrome and recovered with alkylator therapy and a peripheral blood stem cell transplant. The patient’s overall condition was improved at the 1-year follow-up. POEMS syndrome should be considered if a patient presents with endocrinopathy and unexplained peripheral neuropathy. |
format | Online Article Text |
id | pubmed-7871093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-78710932021-02-19 Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report Shi, Huan Jiang, Xiaohong Wang, Long Zhou, Jiayan J Int Med Res Case Report POEMS syndrome is a rare multisystem disease associated with an underlying plasma cell disorder. Its name is an acronym for peripheral neuropathy (P), endocrinopathy (E), organomegaly (O), monoclonal plasma cell proliferative disorder (M), and skin changes (S). This case report describes a patient with POEMS syndrome who presented with progressive fatigue and numbness in the lower extremities. Initially, the patient was erroneously diagnosed with diabetes and diabetic peripheral neuropathy because of the endocrinopathy associated with POEMS syndrome. After a second hospitalization, the patient was diagnosed with POEMS syndrome and recovered with alkylator therapy and a peripheral blood stem cell transplant. The patient’s overall condition was improved at the 1-year follow-up. POEMS syndrome should be considered if a patient presents with endocrinopathy and unexplained peripheral neuropathy. SAGE Publications 2021-02-02 /pmc/articles/PMC7871093/ /pubmed/33530791 http://dx.doi.org/10.1177/0300060520986706 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Shi, Huan Jiang, Xiaohong Wang, Long Zhou, Jiayan Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report |
title | Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report |
title_full | Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report |
title_fullStr | Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report |
title_full_unstemmed | Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report |
title_short | Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report |
title_sort | missed diagnosis of poems syndrome with onset of progressive fatigue and numbness: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871093/ https://www.ncbi.nlm.nih.gov/pubmed/33530791 http://dx.doi.org/10.1177/0300060520986706 |
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