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Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report

POEMS syndrome is a rare multisystem disease associated with an underlying plasma cell disorder. Its name is an acronym for peripheral neuropathy (P), endocrinopathy (E), organomegaly (O), monoclonal plasma cell proliferative disorder (M), and skin changes (S). This case report describes a patient w...

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Detalles Bibliográficos
Autores principales: Shi, Huan, Jiang, Xiaohong, Wang, Long, Zhou, Jiayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871093/
https://www.ncbi.nlm.nih.gov/pubmed/33530791
http://dx.doi.org/10.1177/0300060520986706
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author Shi, Huan
Jiang, Xiaohong
Wang, Long
Zhou, Jiayan
author_facet Shi, Huan
Jiang, Xiaohong
Wang, Long
Zhou, Jiayan
author_sort Shi, Huan
collection PubMed
description POEMS syndrome is a rare multisystem disease associated with an underlying plasma cell disorder. Its name is an acronym for peripheral neuropathy (P), endocrinopathy (E), organomegaly (O), monoclonal plasma cell proliferative disorder (M), and skin changes (S). This case report describes a patient with POEMS syndrome who presented with progressive fatigue and numbness in the lower extremities. Initially, the patient was erroneously diagnosed with diabetes and diabetic peripheral neuropathy because of the endocrinopathy associated with POEMS syndrome. After a second hospitalization, the patient was diagnosed with POEMS syndrome and recovered with alkylator therapy and a peripheral blood stem cell transplant. The patient’s overall condition was improved at the 1-year follow-up. POEMS syndrome should be considered if a patient presents with endocrinopathy and unexplained peripheral neuropathy.
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spelling pubmed-78710932021-02-19 Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report Shi, Huan Jiang, Xiaohong Wang, Long Zhou, Jiayan J Int Med Res Case Report POEMS syndrome is a rare multisystem disease associated with an underlying plasma cell disorder. Its name is an acronym for peripheral neuropathy (P), endocrinopathy (E), organomegaly (O), monoclonal plasma cell proliferative disorder (M), and skin changes (S). This case report describes a patient with POEMS syndrome who presented with progressive fatigue and numbness in the lower extremities. Initially, the patient was erroneously diagnosed with diabetes and diabetic peripheral neuropathy because of the endocrinopathy associated with POEMS syndrome. After a second hospitalization, the patient was diagnosed with POEMS syndrome and recovered with alkylator therapy and a peripheral blood stem cell transplant. The patient’s overall condition was improved at the 1-year follow-up. POEMS syndrome should be considered if a patient presents with endocrinopathy and unexplained peripheral neuropathy. SAGE Publications 2021-02-02 /pmc/articles/PMC7871093/ /pubmed/33530791 http://dx.doi.org/10.1177/0300060520986706 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Shi, Huan
Jiang, Xiaohong
Wang, Long
Zhou, Jiayan
Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report
title Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report
title_full Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report
title_fullStr Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report
title_full_unstemmed Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report
title_short Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report
title_sort missed diagnosis of poems syndrome with onset of progressive fatigue and numbness: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871093/
https://www.ncbi.nlm.nih.gov/pubmed/33530791
http://dx.doi.org/10.1177/0300060520986706
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