Cargando…

COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses

Cellular and humoral immunity to SARS-CoV-2 is critical to control primary infection and correlates with severity of disease. The role of SARS-CoV-2-specific T cell immunity, its relationship to antibodies, and pre-existing immunity against endemic coronaviruses (huCoV), which has been hypothesized...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bonifacius, Agnes, Tischer-Zimmermann, Sabine, Dragon, Anna C., Gussarow, Daniel, Vogel, Alexander, Krettek, Ulrike, Gödecke, Nina, Yilmaz, Mustafa, Kraft, Anke R.M., Hoeper, Marius M., Pink, Isabell, Schmidt, Julius J., Li, Yang, Welte, Tobias, Maecker-Kolhoff, Britta, Martens, Jörg, Berger, Marc Moritz, Lobenwein, Corinna, Stankov, Metodi V., Cornberg, Markus, David, Sascha, Behrens, Georg M.N., Witzke, Oliver, Blasczyk, Rainer, Eiz-Vesper, Britta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871825/ https://www.ncbi.nlm.nih.gov/pubmed/33567252 http://dx.doi.org/10.1016/j.immuni.2021.01.008

Ejemplares similares

Long-Lasting Immunity Against SARS-CoV-2: Dream or Reality?
por: Gussarow, Daniel, et al.
Publicado: (2021)

Adoptive T-cell immunotherapy from third-party donors: characterization of donors and set up of a T-cell donor registry
por: Eiz-Vesper, Britta, et al.
Publicado: (2013)

Robust Identification of Suitable T-Cell Subsets for Personalized CMV-Specific T-Cell Immunotherapy Using CD45RA and CD62L Microbeads
por: Mangare, Caroline, et al.
Publicado: (2019)

Heat shock protein 70/peptide complexes: potent mediators for the generation of antiviral T cells particularly with regard to low precursor frequencies
por: Tischer, Sabine, et al.
Publicado: (2011)

Personalized adoptive immunotherapy for patients with EBV-associated tumors and complications: Evaluation of novel naturally processed and presented EBV-derived T-cell epitopes
por: Bieling, Maren, et al.
Publicado: (2017)

Reinforcement of cell-mediated immunity driven by tumor-associated Epstein-Barr virus (EBV)-specific T cells during targeted B-cell therapy with rituximab
por: Tischer-Zimmermann, Sabine, et al.
Publicado: (2023)

Selective Effects of mTOR Inhibitor Sirolimus on Naïve and CMV-Specific T Cells Extending Its Applicable Range Beyond Immunosuppression
por: Bak, Szilvia, et al.
Publicado: (2018)

Discovery of immunodominant T-cell epitopes reveals penton protein as a second immunodominant target in human adenovirus infection
por: Tischer, Sabine, et al.
Publicado: (2016)

Inhibition of Heme Oxygenase-1 Activity Enhances Wilms Tumor-1-Specific T-Cell Responses in Cancer Immunotherapy
por: Schillingmann, Damaris A., et al.
Publicado: (2019)

CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation
por: Dragon, Anna Christina, et al.
Publicado: (2020)

Enhancement of Antiviral T-Cell Responses by Vitamin C Suggests New Strategies to Improve Manufacturing of Virus-Specific T Cells for Adoptive Immunotherapy
por: Laubert, Miriam, et al.
Publicado: (2022)

Antiviral T-Cell Frequencies in a Healthy Population: Reference Values for Evaluating Antiviral Immune Cell Profiles in Immunocompromised Patients
por: Schulze Lammers, Friederike C., et al.
Publicado: (2022)

High-intensity interval training in allogeneic adoptive T-cell immunotherapy – a big HIT?
por: Heinemann, Nele Carolin, et al.
Publicado: (2020)

Rapid generation of clinical-grade antiviral T cells: selection of suitable T-cell donors and GMP-compliant manufacturing of antiviral T cells
por: Tischer, Sabine, et al.
Publicado: (2014)

Comparative Analysis of Clinical-Scale IFN-γ-Positive T-Cell Enrichment Using Partially and Fully Integrated Platforms
por: Priesner, Christoph, et al.
Publicado: (2016)

Adoptive Allogeneic T-Cell Therapy Improves the Clinical Outcome of JC Virus Granule Cell Neuronopathy: A Case Report
por: Grote-Levi, Lea, et al.
Publicado: (2023)

Refractory Epstein-Barr Virus (EBV)-Related Post-transplant Lymphoproliferative Disease: Cure by Combined Brentuximab Vedotin and Allogeneic EBV-Specific T-Lymphocytes
por: Mika, Thomas, et al.
Publicado: (2019)

Impaired Functionality of Antiviral T Cells in G-CSF Mobilized Stem Cell Donors: Implications for the Selection of CTL Donor
por: Bunse, Carola E., et al.
Publicado: (2013)

Rapid and sustained T cell-based immunotherapy against invasive fungal disease via a combined two step procedure
por: Tischer-Zimmermann, Sabine, et al.
Publicado: (2023)

Long-Term Follow-Up after Adoptive Transfer of BK-Virus-Specific T Cells in Hematopoietic Stem Cell Transplant Recipients
por: Koldehoff, Michael, et al.
Publicado: (2023)

Rapid Manufacturing of Highly Cytotoxic Clinical-Grade SARS-CoV-2-specific T Cell Products Covering SARS-CoV-2 and Its Variants for Adoptive T Cell Therapy
por: Bonifacius, Agnes, et al.
Publicado: (2022)

CAR-Ts redirected against the Thomsen-Friedenreich antigen CD176 mediate specific elimination of malignant cells from leukemia and solid tumors
por: Dragon, Anna Christina, et al.
Publicado: (2023)

Reduced humoral but stable cellular SARS-CoV-2-specific immunity in liver transplant recipients in the first year after COVID-19
por: Kirchner, Theresa, et al.
Publicado: (2022)

Allogeneic BK Virus-Specific T-Cell Treatment in 2 Patients With Progressive Multifocal Leukoencephalopathy
por: Hopfner, Franziska, et al.
Publicado: (2021)

Dissecting Epstein-Barr Virus-Specific T-Cell Responses After Allogeneic EBV-Specific T-Cell Transfer for Central Nervous System Posttransplant Lymphoproliferative Disease
por: Schultze-Florey, Rebecca E., et al.
Publicado: (2018)

Adoptive Cell Transfer of Allogeneic Epstein–Barr Virus-Specific T Lymphocytes for Treatment of Refractory EBV-Associated Posttransplant Smooth Muscle Tumors: A Case Report
por: Hansen, Bjoern-Thore, et al.
Publicado: (2021)

HSP70 Enhances Immunosuppressive Function of CD4(+)CD25(+)FoxP3(+) T Regulatory Cells and Cytotoxicity in CD4(+)CD25(−) T Cells
por: Wachstein, Julian, et al.
Publicado: (2012)

Combined Treatment With Pembrolizumab and Allogenic BK Virus-Specific T Cells in Progressive Multifocal Leukoencephalopathy: A Case Report
por: Wicklein, Rebecca, et al.
Publicado: (2021)

Innovative therapeutic concepts of progressive multifocal leukoencephalopathy
por: Möhn, Nora, et al.
Publicado: (2022)

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) specific cellular and humoral immunity in Corovavirus Disease-2019 (COVID-19) convalescence after liver transplantation-a prospective six month follow-up
por: Kirchner, Theresa, et al.
Publicado: (2022)

Secreted β(3)-Integrin Enhances Natural Killer Cell Activity against Acute Myeloid Leukemia Cells
por: Skaik, Younis, et al.
Publicado: (2014)

Stem Cell Therapy in Neuroimmunological Diseases and Its Potential Neuroimmunological Complications
por: Konen, Franz Felix, et al.
Publicado: (2022)

Posttransplant Lymphoproliferative Disease after Pediatric Solid Organ Transplantation
por: Mynarek, Martin, et al.
Publicado: (2013)

Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors
por: Bonifacius, Agnes, et al.
Publicado: (2023)

SARS-CoV-2-specific immunity in immunosuppressed COVID-19 convalescents with autoimmune hepatitis
por: Kirchner, Theresa, et al.
Publicado: (2021)

NKG2A silencing in effector cells to improve effectivity of cell based therapeutics
por: Figueiredo, C, et al.
Publicado: (2009)

Human calreticulin can act as adjuvant in the maturation of antigen presenting cells
por: Bajor, A, et al.
Publicado: (2009)

Heat Shock Protein 70 (HSP70) induces cytotoxicity of T-helper cells
por: Figueiredo, C, et al.
Publicado: (2009)

High genetic stability of co-circulating human adenovirus type 31 lineages over 59 years
por: Götting, Jasper, et al.
Publicado: (2022)

Gene conversion of the major histocompatibility complex class I Caja‐G in common marmosets (Callithrix jacchus)
por: Neehus, Anna‐Lena, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_h9idcb30c9du0gukk9i06od56k