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Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had been previously exposed to other antigenically distinct common seasonal human coronaviruses (hCoVs) before the coronavirus disease...

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Autores principales: Anderson, Elizabeth M., Goodwin, Eileen C., Verma, Anurag, Arevalo, Claudia P., Bolton, Marcus J., Weirick, Madison E., Gouma, Sigrid, McAllister, Christopher M., Christensen, Shannon R., Weaver, JoEllen, Hicks, Philip, Manzoni, Tomaz B., Oniyide, Oluwatosin, Ramage, Holly, Mathew, Divij, Baxter, Amy E., Oldridge, Derek A., Greenplate, Allison R., Wu, Jennifer E., Alanio, Cécile, D’Andrea, Kurt, Kuthuru, Oliva, Dougherty, Jeanette, Pattekar, Ajinkya, Kim, Justin, Han, Nicholas, Apostolidis, Sokratis A., Huang, Alex C., Vella, Laura A., Kuri-Cervantes, Leticia, Pampena, M. Betina, Betts, Michael R., Wherry, E. John, Meyer, Nuala J., Cherry, Sara, Bates, Paul, Rader, Daniel J., Hensley, Scott E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871851/
https://www.ncbi.nlm.nih.gov/pubmed/33631096
http://dx.doi.org/10.1016/j.cell.2021.02.010
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author Anderson, Elizabeth M.
Goodwin, Eileen C.
Verma, Anurag
Arevalo, Claudia P.
Bolton, Marcus J.
Weirick, Madison E.
Gouma, Sigrid
McAllister, Christopher M.
Christensen, Shannon R.
Weaver, JoEllen
Hicks, Philip
Manzoni, Tomaz B.
Oniyide, Oluwatosin
Ramage, Holly
Mathew, Divij
Baxter, Amy E.
Oldridge, Derek A.
Greenplate, Allison R.
Wu, Jennifer E.
Alanio, Cécile
D’Andrea, Kurt
Kuthuru, Oliva
Dougherty, Jeanette
Pattekar, Ajinkya
Kim, Justin
Han, Nicholas
Apostolidis, Sokratis A.
Huang, Alex C.
Vella, Laura A.
Kuri-Cervantes, Leticia
Pampena, M. Betina
Betts, Michael R.
Wherry, E. John
Meyer, Nuala J.
Cherry, Sara
Bates, Paul
Rader, Daniel J.
Hensley, Scott E.
author_facet Anderson, Elizabeth M.
Goodwin, Eileen C.
Verma, Anurag
Arevalo, Claudia P.
Bolton, Marcus J.
Weirick, Madison E.
Gouma, Sigrid
McAllister, Christopher M.
Christensen, Shannon R.
Weaver, JoEllen
Hicks, Philip
Manzoni, Tomaz B.
Oniyide, Oluwatosin
Ramage, Holly
Mathew, Divij
Baxter, Amy E.
Oldridge, Derek A.
Greenplate, Allison R.
Wu, Jennifer E.
Alanio, Cécile
D’Andrea, Kurt
Kuthuru, Oliva
Dougherty, Jeanette
Pattekar, Ajinkya
Kim, Justin
Han, Nicholas
Apostolidis, Sokratis A.
Huang, Alex C.
Vella, Laura A.
Kuri-Cervantes, Leticia
Pampena, M. Betina
Betts, Michael R.
Wherry, E. John
Meyer, Nuala J.
Cherry, Sara
Bates, Paul
Rader, Daniel J.
Hensley, Scott E.
author_sort Anderson, Elizabeth M.
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had been previously exposed to other antigenically distinct common seasonal human coronaviruses (hCoVs) before the coronavirus disease 2019 (COVID-19) pandemic. Here, we quantified levels of SARS-CoV-2-reactive antibodies and hCoV-reactive antibodies in serum samples collected from 431 humans before the COVID-19 pandemic. We then quantified pre-pandemic antibody levels in serum from a separate cohort of 251 individuals who became PCR-confirmed infected with SARS-CoV-2. Finally, we longitudinally measured hCoV and SARS-CoV-2 antibodies in the serum of hospitalized COVID-19 patients. Our studies indicate that most individuals possessed hCoV-reactive antibodies before the COVID-19 pandemic. We determined that ∼20% of these individuals possessed non-neutralizing antibodies that cross-reacted with SARS-CoV-2 spike and nucleocapsid proteins. These antibodies were not associated with protection against SARS-CoV-2 infections or hospitalizations, but they were boosted upon SARS-CoV-2 infection.
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spelling pubmed-78718512021-02-10 Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection Anderson, Elizabeth M. Goodwin, Eileen C. Verma, Anurag Arevalo, Claudia P. Bolton, Marcus J. Weirick, Madison E. Gouma, Sigrid McAllister, Christopher M. Christensen, Shannon R. Weaver, JoEllen Hicks, Philip Manzoni, Tomaz B. Oniyide, Oluwatosin Ramage, Holly Mathew, Divij Baxter, Amy E. Oldridge, Derek A. Greenplate, Allison R. Wu, Jennifer E. Alanio, Cécile D’Andrea, Kurt Kuthuru, Oliva Dougherty, Jeanette Pattekar, Ajinkya Kim, Justin Han, Nicholas Apostolidis, Sokratis A. Huang, Alex C. Vella, Laura A. Kuri-Cervantes, Leticia Pampena, M. Betina Betts, Michael R. Wherry, E. John Meyer, Nuala J. Cherry, Sara Bates, Paul Rader, Daniel J. Hensley, Scott E. Cell Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had been previously exposed to other antigenically distinct common seasonal human coronaviruses (hCoVs) before the coronavirus disease 2019 (COVID-19) pandemic. Here, we quantified levels of SARS-CoV-2-reactive antibodies and hCoV-reactive antibodies in serum samples collected from 431 humans before the COVID-19 pandemic. We then quantified pre-pandemic antibody levels in serum from a separate cohort of 251 individuals who became PCR-confirmed infected with SARS-CoV-2. Finally, we longitudinally measured hCoV and SARS-CoV-2 antibodies in the serum of hospitalized COVID-19 patients. Our studies indicate that most individuals possessed hCoV-reactive antibodies before the COVID-19 pandemic. We determined that ∼20% of these individuals possessed non-neutralizing antibodies that cross-reacted with SARS-CoV-2 spike and nucleocapsid proteins. These antibodies were not associated with protection against SARS-CoV-2 infections or hospitalizations, but they were boosted upon SARS-CoV-2 infection. Elsevier Inc. 2021-04-01 2021-02-09 /pmc/articles/PMC7871851/ /pubmed/33631096 http://dx.doi.org/10.1016/j.cell.2021.02.010 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Anderson, Elizabeth M.
Goodwin, Eileen C.
Verma, Anurag
Arevalo, Claudia P.
Bolton, Marcus J.
Weirick, Madison E.
Gouma, Sigrid
McAllister, Christopher M.
Christensen, Shannon R.
Weaver, JoEllen
Hicks, Philip
Manzoni, Tomaz B.
Oniyide, Oluwatosin
Ramage, Holly
Mathew, Divij
Baxter, Amy E.
Oldridge, Derek A.
Greenplate, Allison R.
Wu, Jennifer E.
Alanio, Cécile
D’Andrea, Kurt
Kuthuru, Oliva
Dougherty, Jeanette
Pattekar, Ajinkya
Kim, Justin
Han, Nicholas
Apostolidis, Sokratis A.
Huang, Alex C.
Vella, Laura A.
Kuri-Cervantes, Leticia
Pampena, M. Betina
Betts, Michael R.
Wherry, E. John
Meyer, Nuala J.
Cherry, Sara
Bates, Paul
Rader, Daniel J.
Hensley, Scott E.
Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
title Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
title_full Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
title_fullStr Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
title_full_unstemmed Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
title_short Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection
title_sort seasonal human coronavirus antibodies are boosted upon sars-cov-2 infection but not associated with protection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871851/
https://www.ncbi.nlm.nih.gov/pubmed/33631096
http://dx.doi.org/10.1016/j.cell.2021.02.010
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